Janakiram R Vangala
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Explore the profile of Janakiram R Vangala including associated specialties, affiliations and a list of published articles.
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9
Citations
174
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Recent Articles
1.
Ward M, Vangala J, Kamber Kaya H, Byers H, Hosseini N, Diaz A, et al.
J Cell Biol
. 2024 Apr;
223(6).
PMID: 38656405
Cells exposed to proteotoxic stress invoke adaptive responses aimed at restoring proteostasis. Our previous studies have established a firm role for the transcription factor Nuclear factor-erythroid derived-2-related factor-1 (Nrf1) in...
2.
Byers H, Brooks A, Vangala J, Grible J, Feygin A, Clevenger C, et al.
Sci Rep
. 2023 Sep;
13(1):15843.
PMID: 37739987
Proteasomes are multi-subunit complexes that specialize in protein degradation. Cancer cells exhibit a heightened dependence on proteasome activity, presumably to support their enhanced proliferation and other cancer-related characteristics. Here, a...
3.
Vangala J, Potluri A, Radhakrishnan S
Biomolecules
. 2020 Apr;
10(4).
PMID: 32224969
Currently proteasome inhibitors bortezomib, carfilzomib, and ixazomib are successfully used in clinics to treat multiple myeloma. However, these agents show limited efficacy against solid tumors. Identification of drugs that can...
4.
Northrop A, Vangala J, Feygin A, Radhakrishnan S
Int J Mol Sci
. 2020 Jan;
21(1).
PMID: 31947743
Proteasome inhibition is used therapeutically to induce proteotoxic stress and trigger apoptosis in cancer cells that are highly dependent on the proteasome. As a mechanism of resistance, inhibition of the...
5.
Vangala J, Radhakrishnan S
J Biol Chem
. 2018 Dec;
294(6):2036-2045.
PMID: 30559296
Inhibition of the proteasome leads to proteotoxic stress, which is characterized by the buildup of ubiquitinated proteins that cannot be degraded properly. The transcription factor Nrf1 (also called NFE2L1) counteracts...
6.
Tomlin F, Gerling-Driessen U, Liu Y, Flynn R, Vangala J, Lentz C, et al.
ACS Cent Sci
. 2017 Dec;
3(11):1143-1155.
PMID: 29202016
Proteasome inhibitors are used to treat blood cancers such as multiple myeloma (MM) and mantle cell lymphoma. The efficacy of these drugs is frequently undermined by acquired resistance. One mechanism...
7.
Vangala J, Sotzny F, Kruger E, Deshaies R, Radhakrishnan S
Curr Biol
. 2016 Sep;
26(18):R834-R835.
PMID: 27676297
In response to proteasome inhibition, the transcription factor Nrf1 facilitates de novo synthesis of proteasomes by inducing proteasome subunit (PSM) genes [1,2]. Previously, we showed that activation of the p120...
8.
Rekha K, Rao R, Pandey R, Prasad K, Babu K, Vangala J, et al.
J Asian Nat Prod Res
. 2013 Feb;
15(2):111-6.
PMID: 23431964
Phytochemical investigation of CHCl(3):MeOH (1:1) extract from the rhizomes of Nardostachys jatamansi led to the isolation of two new sesquiterpenoids (5 and 6), along with six known compounds (1-4, 7,...
9.
Yadav J, Boyapelly K, Alugubelli S, Pabbaraja S, Vangala J, Kalivendi S
J Org Chem
. 2011 Mar;
76(8):2568-76.
PMID: 21413759
The first total synthesis of recently isolated diacetylene alcohols oploxyne A, oploxyne B, and their C-10 epimers was accomplished. The structure of natural oploxyne B has been revised. The key...