Alex Feygin
Overview
Explore the profile of Alex Feygin including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
207
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Recent Articles
1.
Byers H, Brooks A, Vangala J, Grible J, Feygin A, Clevenger C, et al.
Sci Rep
. 2023 Sep;
13(1):15843.
PMID: 37739987
Proteasomes are multi-subunit complexes that specialize in protein degradation. Cancer cells exhibit a heightened dependence on proteasome activity, presumably to support their enhanced proliferation and other cancer-related characteristics. Here, a...
2.
Lechuga S, Naydenov N, Feygin A, Cruise M, Ervasti J, Ivanov A
Front Cell Dev Biol
. 2020 Nov;
8:588836.
PMID: 33195251
Intestinal epithelial barrier is critical for the maintenance of normal gut homeostasis and disruption of this barrier may trigger or exaggerate mucosal inflammation. The actin cytoskeleton is a key regulator...
3.
Cao X, Sun L, Lechuga S, Naydenov N, Feygin A, Ivanov A
Inflamm Bowel Dis
. 2020 Apr;
26(9):1340-1352.
PMID: 32266946
Background: Disruption of the gut barrier is an essential mechanism of inflammatory bowel diseases (IBDs) contributing to the development of mucosal inflammation. A hallmark of barrier disruption is the disassembly...
4.
Northrop A, Vangala J, Feygin A, Radhakrishnan S
Int J Mol Sci
. 2020 Jan;
21(1).
PMID: 31947743
Proteasome inhibition is used therapeutically to induce proteotoxic stress and trigger apoptosis in cancer cells that are highly dependent on the proteasome. As a mechanism of resistance, inhibition of the...
5.
Sun L, Cao X, Lechuga S, Feygin A, Naydenov N, Ivanov A
Cells
. 2020 Jan;
9(1).
PMID: 31905721
Septins are GTP-binding proteins that self-assemble into high-order cytoskeletal structures, filaments, and rings. The septin cytoskeleton has a number of cellular functions, including regulation of cytokinesis, cell migration, vesicle trafficking,...
6.
Naydenov N, Joshi S, Feygin A, Saini S, Litovchick L, Ivanov A
Cell Cycle
. 2018 Jul;
17(14):1812-1831.
PMID: 30010460
Vesicle trafficking regulates epithelial cell migration by remodeling matrix adhesions and delivering signaling molecules to the migrating leading edge. Membrane fusion, which is driven by soluble N-ethylmaleimide-sensitive factor associated receptor...
7.
Lechuga S, Naydenov N, Feygin A, Jimenez A, Ivanov A
Biochem Biophys Res Commun
. 2017 Apr;
486(4):951-957.
PMID: 28359759
A soluble N-ethylmaleimide-sensitive factor-attachment protein alpha (αSNAP) is a multifunctional scaffolding protein that regulates intracellular vesicle trafficking and signaling. In cultured intestinal epithelial cells, αSNAP has been shown to be...
8.
Naydenov N, Feygin A, Wang D, Kuemmerle J, Harris G, Conti M, et al.
Sci Rep
. 2016 Apr;
6:24161.
PMID: 27063635
The actin cytoskeleton is a critical regulator of intestinal mucosal barrier permeability, and the integrity of epithelial adherens junctions (AJ) and tight junctions (TJ). Non muscle myosin II (NM II)...
9.
Wang D, Naydenov N, Feygin A, Baranwal S, Kuemmerle J, Ivanov A
Am J Pathol
. 2016 Feb;
186(4):844-58.
PMID: 26878213
The actin cytoskeleton is a crucial regulator of the intestinal mucosal barrier, controlling the assembly and function of epithelial adherens and tight junctions (AJs and TJs). Junction-associated actin filaments are...
10.
Wang D, Chadha G, Feygin A, Ivanov A
Cell Mol Life Sci
. 2015 Mar;
72(16):3185-3200.
PMID: 25809162
Tight junctions (TJ) and adherens junctions (AJ) are key morphological features of differentiated epithelial cells that regulate the integrity and permeability of tissue barriers. Structure and remodeling of epithelial junctions...