Holly A Byers
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Explore the profile of Holly A Byers including associated specialties, affiliations and a list of published articles.
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6
Citations
62
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Recent Articles
1.
Ward M, Vangala J, Kamber Kaya H, Byers H, Hosseini N, Diaz A, et al.
J Cell Biol
. 2024 Apr;
223(6).
PMID: 38656405
Cells exposed to proteotoxic stress invoke adaptive responses aimed at restoring proteostasis. Our previous studies have established a firm role for the transcription factor Nuclear factor-erythroid derived-2-related factor-1 (Nrf1) in...
2.
Li J, Purser N, Liwocha J, Scott D, Byers H, Steigenberger B, et al.
Mol Cell
. 2024 Feb;
84(7):1304-1320.e16.
PMID: 38382526
Cullin-RING ligases (CRLs) ubiquitylate specific substrates selected from other cellular proteins. Substrate discrimination and ubiquitin transferase activity were thought to be strictly separated. Substrates are recognized by substrate receptors, such...
3.
Byers H, Brooks A, Vangala J, Grible J, Feygin A, Clevenger C, et al.
Sci Rep
. 2023 Sep;
13(1):15843.
PMID: 37739987
Proteasomes are multi-subunit complexes that specialize in protein degradation. Cancer cells exhibit a heightened dependence on proteasome activity, presumably to support their enhanced proliferation and other cancer-related characteristics. Here, a...
4.
Boyd D, Zboril E, Olex A, Leftwich T, Hairr N, Byers H, et al.
Cancers (Basel)
. 2023 Mar;
15(5).
PMID: 36900375
Basal-like triple-negative breast cancer (TNBC) tumor cells are difficult to eliminate due to resistance mechanisms that promote survival. While this breast cancer subtype has low PIK3CA mutation rates when compared...
5.
Northrop A, Byers H, Radhakrishnan S
Mol Biol Cell
. 2020 Sep;
31(20):2158-2163.
PMID: 32924844
The ability to sense proteasome insufficiency and respond by directing the transcriptional synthesis of de novo proteasomes is a trait that is conserved in evolution and is found in organisms...
6.
Rose R, Salvatore J, Aaltonen S, Barr P, Bogl L, Byers H, et al.
Twin Res Hum Genet
. 2019 Oct;
22(5):302-311.
PMID: 31640839
This review offers an update on research conducted with FinnTwin12 (FT12), the youngest of the three Finnish Twin Cohorts. FT12 was designed as a two-stage study. In the first stage,...