Jan Silhavy
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Explore the profile of Jan Silhavy including associated specialties, affiliations and a list of published articles.
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Articles
47
Citations
405
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Recent Articles
11.
Silhavy J, Mlejnek P, Simakova M, Liska F, Kubovciak J, Sticova E, et al.
Biomedicines
. 2022 Feb;
10(2).
PMID: 35203585
Recent studies in humans and rats suggested that increased Na storage in the skin without parallel water retention may predispose to salt-sensitive hypertension. In the current studies, we compared tissue...
12.
Markovic A, Tauchmannova K, Simakova M, Mlejnek P, Kaplanova V, Pecina P, et al.
Biomedicines
. 2022 Feb;
10(2).
PMID: 35203486
Mutations of the gene disrupt the biogenesis of the ATP synthase and represent the most frequent cause of autosomal recessive encephalo-cardio-myopathy with neonatal onset. Patient tissues show isolated defects in...
13.
Dahale S, Ruiz-Orera J, Silhavy J, Hubner N, van Heesch S, Pravenec M, et al.
Life Sci Alliance
. 2022 Jan;
5(4).
PMID: 34996843
The role of alternative promoter usage in tissue-specific gene expression has been well established; however, its role in complex diseases is poorly understood. We performed cap analysis of gene expression...
14.
Neckar J, Alanova P, Olejnickova V, Papousek F, Hejnova L, Silhavy J, et al.
Clin Sci (Lond)
. 2021 Sep;
135(17):2143-2163.
PMID: 34486670
Increased level of C-reactive protein (CRP) is a risk factor for cardiovascular diseases, including myocardial infarction and hypertension. Here, we analyzed the effects of CRP overexpression on cardiac susceptibility to...
15.
Witte F, Ruiz-Orera J, Mattioli C, Blachut S, Adami E, Schulz J, et al.
Genome Biol
. 2021 Jun;
22(1):191.
PMID: 34183069
Background: Little is known about the impact of trans-acting genetic variation on the rates with which proteins are synthesized by ribosomes. Here, we investigate the influence of such distant genetic...
16.
Krizova J, Hulkova M, capek V, Mlejnek P, Silhavy J, Tesarova M, et al.
Biology (Basel)
. 2021 Jun;
10(5).
PMID: 34066731
At the end of the mammalian intra-uterine foetal development, a rapid switch from glycolytic to oxidative metabolism must proceed. Using microarray techniques, qPCR, enzyme activities and coenzyme Q content measurements,...
17.
Junkova K, Mirchi L, Chylikova B, Janku M, Silhavy J, Huttl M, et al.
Nutrients
. 2021 Apr;
13(5).
PMID: 33923085
Metabolic syndrome (MetS) is an important cause of worldwide morbidity and mortality. Its complex pathogenesis includes, on the one hand, sedentary lifestyle and high caloric intake, and, on the other...
18.
Mihola O, Landa V, Pratto F, Brick K, Kobets T, Kusari F, et al.
BMC Biol
. 2021 Apr;
19(1):86.
PMID: 33910563
Background: Vertebrate meiotic recombination events are concentrated in regions (hotspots) that display open chromatin marks, such as trimethylation of lysines 4 and 36 of histone 3 (H3K4me3 and H3K36me3). Mouse...
19.
Silhavy J, Malinska H, Huttl M, Markova I, Oliyarnyk O, Mlejnek P, et al.
Antioxidants (Basel)
. 2020 Dec;
9(12).
PMID: 33255888
Methylglyoxal (MG), a potent precursor of advanced glycation end-products (AGE), is increased in metabolic disorders such as diabetes and obesity. MG and other dicarbonyl metabolites are detoxified by the glyoxalase...
20.
Liska F, Peterkova R, Peterka M, Landa V, Zidek V, Mlejnek P, et al.
PLoS One
. 2020 Jan;
15(1):e0228139.
PMID: 31945126
[This corrects the article DOI: 10.1371/journal.pone.0164206.].