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Jan Silhavy

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Articles 47
Citations 405
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Recent Articles
21.
Morris Jr R, Pravenec M, Silhavy J, DiCarlo S, Kurtz T
Hypertension . 2019 Mar; 73(5):1042-1048. PMID: 30917704
To reduce the risk of salt-induced hypertension, medical authorities have emphasized dietary guidelines promoting high intakes of potassium and low intakes of salt that provide molar ratios of potassium to...
22.
Nedvedova I, Kolar D, Neckar J, Kalous M, Pravenec M, Silhavy J, et al.
Front Endocrinol (Lausanne) . 2019 Feb; 9:809. PMID: 30723458
Adaptation to continuous normobaric hypoxia (CNH) protects the heart against acute ischemia/reperfusion injury. Recently, we have demonstrated the infarct size-limiting effect of CNH also in hearts of spontaneously hypertensive rats...
23.
Adriaens M, Lodder E, Moreno-Moral A, Silhavy J, Heinig M, Glinge C, et al.
J Am Heart Assoc . 2019 Jan; 7(21):e009243. PMID: 30608189
Background Electrocardiographic ( ECG ) parameters are regarded as intermediate phenotypes of cardiac arrhythmias. Insight into the genetic underpinnings of these parameters is expected to contribute to the understanding of...
24.
Lusk R, Saba L, Vanderlinden L, Zidek V, Silhavy J, Pravenec M, et al.
Alcohol Clin Exp Res . 2018 Apr; 42(7):1177-1191. PMID: 29689131
Background: A statistical pipeline was developed and used for determining candidate genes and candidate gene coexpression networks involved in 2 alcohol (i.e., ethanol [EtOH]) metabolism phenotypes, namely alcohol clearance and...
25.
Kuda O, Brezinova M, Silhavy J, Landa V, Zidek V, Dodia C, et al.
Diabetes . 2018 Mar; 67(6):1190-1199. PMID: 29549163
Fatty acid esters of hydroxy fatty acids (FAHFAs) are lipid mediators with promising antidiabetic and anti-inflammatory properties that are formed in white adipose tissue (WAT) via de novo lipogenesis, but...
26.
Pravenec M, Saba L, Zidek V, Landa V, Mlejnek P, Silhavy J, et al.
Physiol Genomics . 2017 Nov; 50(1):52-66. PMID: 29127223
Brown adipose tissue (BAT) has been suggested to play an important role in lipid and glucose metabolism in rodents and possibly also in humans. In the current study, we used...
27.
Trnovska J, Silhavy J, Kuda O, Landa V, Zidek V, Mlejnek P, et al.
PLoS One . 2017 Jun; 12(6):e0179063. PMID: 28586387
Chronic low-grade inflammation plays an important role in the pathogenesis of insulin resistance. In the current study, we tested the effects of salsalate, a non-steroidal anti-inflammatory drug, in an animal...
28.
Hahnova K, Brabcova I, Neckar J, Weissova R, Svatonova A, Novakova O, et al.
J Physiol Sci . 2017 Jun; 68(4):441-454. PMID: 28567570
The β-adrenergic signaling pathways and antioxidant defence mechanisms play important roles in maintaining proper heart function. Here, we examined the effect of chronic normobaric hypoxia (CNH, 10% O, 3 weeks)...
29.
Liska F, Landa V, Zidek V, Mlejnek P, Silhavy J, Simakova M, et al.
Hypertension . 2017 Apr; 69(6):1084-1091. PMID: 28396530
The spontaneously hypertensive rat (SHR), one of the most widely used model of essential hypertension, is predisposed to left ventricular hypertrophy, myocardial fibrosis, and metabolic disturbances. Recently, quantitative trait loci...
30.
Neckar J, Svatonova A, Weissova R, Drahota Z, Zajickova P, Brabcova I, et al.
Clin Sci (Lond) . 2017 Mar; 131(9):865-881. PMID: 28292971
Mitochondria play an essential role in improved cardiac ischaemic tolerance conferred by adaptation to chronic hypoxia. In the present study, we analysed the effects of continuous normobaric hypoxia (CNH) on...