Michal Pravenec
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Explore the profile of Michal Pravenec including associated specialties, affiliations and a list of published articles.
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143
Citations
3613
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Recent Articles
1.
Villani F, Guarracino A, Ward R, Green T, Emms M, Pravenec M, et al.
iScience
. 2025 Mar;
28(2):111835.
PMID: 40034122
The HXB/BXH family of recombinant inbred rat strains is a unique genetic resource that has been extensively phenotyped over 25 years, resulting in a vast dataset of quantitative molecular and...
2.
Andelova K, Sykora M, Farkasova V, Stankovicova T, Szeiffova Bacova B, Knezl V, et al.
Biomolecules
. 2025 Jan;
14(12.
PMID: 39766216
Objectives: Due to poor treatment adherence and lifestyle-based interventions, chronic hypertension is a dominant risk factor predisposing individuals to heart failure and malignant arrhythmias. We investigated the impact of the...
3.
Pecina P, Cunatova K, Kaplanova V, Puertas-Frias G, Silhavy J, Tauchmannova K, et al.
Commun Biol
. 2024 Sep;
7(1):1116.
PMID: 39261587
Metabolic syndrome is a growing concern in developed societies and due to its polygenic nature, the genetic component is only slowly being elucidated. Common mitochondrial DNA sequence variants have been...
4.
Nemeckova I, Eissazadeh S, Rathouska J, Silhavy J, Malinska H, Pravenec M, et al.
BMC Cardiovasc Disord
. 2024 Apr;
24(1):211.
PMID: 38627621
Background: C-reactive protein (CRP) is an acute inflammatory protein detected in obese patients with metabolic syndrome. Moreover, increased CRP levels have been linked with atherosclerotic disease, congestive heart failure, and...
5.
de Jong T, Pan Y, Rastas P, Munro D, Tutaj M, Akil H, et al.
Cell Genom
. 2024 Mar;
4(4):100527.
PMID: 38537634
The seventh iteration of the reference genome assembly for Rattus norvegicus-mRatBN7.2-corrects numerous misplaced segments and reduces base-level errors by approximately 9-fold and increases contiguity by 290-fold compared with its predecessor....
6.
Villani F, Guarracino A, Ward R, Green T, Emms M, Pravenec M, et al.
bioRxiv
. 2024 Jan;
PMID: 38260597
The HXB/BXH family of recombinant inbred rat strains is a unique genetic resource that has been extensively phenotyped over 25 years, resulting in a vast dataset of quantitative molecular and...
7.
Silhavy J, Mlejnek P, Simakova M, Liska F, Malinska H, Markova I, et al.
Physiol Genomics
. 2023 Nov;
56(1):65-73.
PMID: 37955133
Recently, we have identified a recessive mutation, an abnormal coat appearance in the BXH6 strain, a member of the HXB/BXH set of recombinant inbred (RI) strains. The RI strains were...
8.
de Jong T, Pan Y, Rastas P, Munro D, Tutaj M, Akil H, et al.
bioRxiv
. 2023 May;
PMID: 37214860
The seventh iteration of the reference genome assembly for -mRatBN7.2-corrects numerous misplaced segments and reduces base-level errors by approximately 9-fold and increases contiguity by 290-fold compared to its predecessor. Gene...
9.
Huttl M, Markova I, Miklankova D, Zapletalova I, Kujal P, Silhavy J, et al.
Front Pharmacol
. 2023 Apr;
14:1117683.
PMID: 37077818
Low-grade chronic inflammation plays an important role in the pathogenesis of metabolic syndrome, type 2 diabetes and their complications. In this study, we investigated the effects of salsalate, a non-steroidal...
10.
Silhavy J, Mlejnek P, Simakova M, Markova I, Malinska H, Huttl M, et al.
PLoS One
. 2023 Apr;
18(4):e0283276.
PMID: 37053180
Thermogenesis in brown adipose tissue (BAT) uses intracellular triglycerides, circulating free fatty acids and glucose as the main substrates. The objective of the current study was to analyse the role...