Jan P Mattsson
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Explore the profile of Jan P Mattsson including associated specialties, affiliations and a list of published articles.
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Citations
520
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Recent Articles
1.
Ovchinsky N, Aumar M, Baker A, Baumann U, Bufler P, Cananzi M, et al.
Lancet Gastroenterol Hepatol
. 2024 Apr;
9(7):632-645.
PMID: 38670135
Background: In patients with Alagille syndrome, cholestasis-associated clinical features can include high serum bile acids and severe pruritus that can necessitate liver transplantation. We aimed to evaluate the efficacy and...
2.
Thompson R, Artan R, Baumann U, Calvo P, Czubkowski P, Dalgic B, et al.
JHEP Rep
. 2023 Jul;
5(8):100782.
PMID: 37456676
Background & Aims: PEDFIC 2, an ongoing, open-label, 72-week study, evaluates odevixibat, an ileal bile acid transporter inhibitor, in patients with progressive familial intrahepatic cholestasis. Methods: PEDFIC 2 enrolled and...
3.
Caballero-Camino F, Rodrigues P, Wangsell F, Agirre-Lizaso A, Olaizola P, Izquierdo-Sanchez L, et al.
Hepatology
. 2023 Mar;
78(3):709-726.
PMID: 36999529
Background And Aims: Cholestasis is characterized by intrahepatic accumulation of bile constituents, including bile acids (BAs), which promote liver damage. The apical sodium-dependent BA transporter (ASBT) plays an important role...
4.
Thompson R, Arnell H, Artan R, Baumann U, Calvo P, Czubkowski P, et al.
Lancet Gastroenterol Hepatol
. 2022 Jul;
7(9):830-842.
PMID: 35780807
Background: Progressive familial intrahepatic cholestasis (PFIC) is a group of inherited paediatric liver diseases resulting from mutations in genes that impact bile secretion. We aimed to evaluate the effects of...
5.
Nakajima A, Ishizaki S, Matsuda K, Kurosu S, Taniguchi S, Gillberg P, et al.
J Gastroenterol Hepatol
. 2022 Feb;
37(5):883-890.
PMID: 35168298
Background And Aim: Elobixibat is a locally acting inhibitor of the ileal bile acid transporter. We compared bile acid metabolism between healthy subjects and patients with chronic constipation and assessed...
6.
Baumann U, Sturm E, Lacaille F, Gonzales E, Arnell H, Fischler B, et al.
Clin Res Hepatol Gastroenterol
. 2021 Jun;
45(5):101751.
PMID: 34182185
Purpose: Ileal bile acid transporter inhibition is a novel therapeutic concept for cholestatic pruritus and cholestatic liver disease progression. Odevixibat, a potent, selective, reversible ileal bile acid transporter inhibitor, decreases...
7.
Verkade H, Thompson R, Arnell H, Fischler B, Gillberg P, Mattsson J, et al.
J Pediatr Gastroenterol Nutr
. 2020 May;
71(2):176-183.
PMID: 32433433
Objectives: We assessed available data on impact of partial external biliary diversion (PEBD) surgery on clinical outcomes in patients with progressive familial intrahepatic cholestasis (PFIC). Methods: We performed a systematic...
8.
Nakajima A, Taniguchi S, Kurosu S, Gillberg P, Mattsson J, Camilleri M
Neurogastroenterol Motil
. 2019 Feb;
31(5):e13571.
PMID: 30793431
Background: In two phase 3 trials, elobixibat, a locally acting ileal bile acid transporter inhibitor, resolved constipation and was well tolerated in Japanese patients with chronic constipation. We analyzed the...
9.
Nakajima A, Seki M, Taniguchi S, Ohta A, Gillberg P, Mattsson J, et al.
Lancet Gastroenterol Hepatol
. 2018 May;
3(8):537-547.
PMID: 29805116
Background: A subset of patients with constipation has reduced colonic bile acid concentrations, which are associated with slow colonic transit. In a previous study, elobixibat, a locally acting ileal bile...
10.
Staaf S, Franck M, Marmigere F, Mattsson J, Ernfors P
Gene Expr Patterns
. 2009 Oct;
10(1):65-74.
PMID: 19850157
Despite the significance of transient receptor potential (TRP) channels in sensory physiology, little is known of the expression and developmental regulation of the TRPM (melastatin) subgroup in sensory neurons. In...