Jan H J Hoeijmakers
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Explore the profile of Jan H J Hoeijmakers including associated specialties, affiliations and a list of published articles.
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180
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11768
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Recent Articles
1.
Oudmaijer C, Komninos D, Ozinga R, Smit K, Rozendaal N, Hoeijmakers J, et al.
Front Immunol
. 2025 Mar;
16:1488324.
PMID: 40051619
Background: Short-Term Fasting (STF) is an intervention reducing the intake of calories, without causing undernutrition or micronutrient-related malnutrition. It aims to systemically improve resilience against acute stress. Several (pre-)clinical studies...
2.
Erkelenz S, Grzonka M, Papadakis A, Schaal H, Hoeijmakers J, Gyenis A
RNA Biol
. 2024 Oct;
21(1):1-13.
PMID: 39387568
(RNA-binding motif protein 3) is a stress responsive gene, which maintains cellular homeostasis and promotes survival upon various harmful cellular stimuli. Rbm3 protein shows conserved structural and molecular similarities to...
3.
Llerena Schiffmacher D, Lee S, Kliza K, Theil A, Akita M, Helfricht A, et al.
Nat Commun
. 2024 Jul;
15(1):6374.
PMID: 39075067
Transcription-blocking DNA lesions are specifically targeted by transcription-coupled nucleotide excision repair (TC-NER), which removes a broad spectrum of DNA lesions to preserve transcriptional output and thereby cellular homeostasis to counteract...
4.
Zhang L, Lee M, Hao X, Ehlert J, Chi Z, Jin B, et al.
bioRxiv
. 2024 May;
PMID: 38766154
Substantial numbers of somatic mutations have been found to accumulate with age in different human tissues. Clonal cellular amplification of some of these mutations can cause cancer and other diseases....
5.
He Y, Yang W, Huang L, Mever M, Ramautar R, Harms A, et al.
J Cachexia Sarcopenia Muscle
. 2024 May;
15(3):868-882.
PMID: 38689513
Background: Sarcopenia is characterized by loss of skeletal muscle mass and function, and is a major risk factor for disability and independence in the elderly. Effective medication is not available....
6.
Soheili-Nezhad S, Ibanez-Sole O, Izeta A, Hoeijmakers J, Stoeger T
Trends Genet
. 2024 Mar;
40(4):299-312.
PMID: 38519330
Recent studies of aging organisms have identified a systematic phenomenon, characterized by a negative correlation between gene length and their expression in various cell types, species, and diseases. We term...
7.
van Thiel B, de Boer M, Ridwan Y, de Kleijnen M, van Vliet N, van der Linden J, et al.
Mol Imaging Biol
. 2024 Mar;
26(4):628-637.
PMID: 38498063
Purpose: In this study, we explored the role of apoptosis as a potential biomarker for cardiac failure using functional micro-CT and fluorescence molecular tomography (FMT) imaging techniques in Ercc1 mutant...
8.
Age-associated transcriptional stress due to accelerated elongation and increased stalling of RNAPII
Papadakis A, Gyenis A, Pothof J, Hoeijmakers J, Papantonis A, Beyer A
Nat Genet
. 2023 Nov;
55(12):2011-2012.
PMID: 38001379
No abstract available.
9.
Schiffmacher D, Lee S, Kliza K, Theil A, Akita M, Helfricht A, et al.
Res Sq
. 2023 Oct;
PMID: 37886519
Transcription-blocking DNA lesions are specifically targeted by transcription-coupled nucleotide excision repair (TC-NER), which removes a broad spectrum of DNA lesions to preserve transcriptional output and thereby cellular homeostasis to counteract...
10.
Barnhoorn S, Meima M, Peeters R, Darras V, Leeuwenburgh S, Hoeijmakers J, et al.
Eur Thyroid J
. 2023 Oct;
12(6).
PMID: 37878415
Background: Thyroid hormone signaling is essential for development, metabolism, and response to stress but declines during aging, the cause of which is unknown. DNA damage accumulating with time is a...