Wim Vermeulen
Overview
Explore the profile of Wim Vermeulen including associated specialties, affiliations and a list of published articles.
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Articles
141
Citations
6977
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Recent Articles
1.
Van Houten B, Vermeulen W
DNA Repair (Amst)
. 2025 Feb;
146:103819.
PMID: 39965461
No abstract available.
2.
Essink B, Vermeulen W, Andrade C, de Rooij R, Isakov L, Casula D, et al.
Vaccine
. 2025 Feb;
51:126791.
PMID: 39946829
Influenza poses a significant global healthcare burden, with up to 1 billion infections annually, and poorer outcomes in vulnerable populations such as older adults. Vaccination effectiveness is often lower in...
3.
Ramadhin A, Lee S, Zhou D, Salmazo A, Gonzalo-Hansen C, van Sluis M, et al.
Mol Cell
. 2024 Nov;
84(24):4740-4757.e12.
PMID: 39547223
Transcription-coupled nucleotide excision repair (TC-NER) efficiently eliminates DNA damage that impedes gene transcription by RNA polymerase II (RNA Pol II). TC-NER is initiated by the recognition of lesion-stalled RNA Pol...
4.
Llerena Schiffmacher D, Lee S, Kliza K, Theil A, Akita M, Helfricht A, et al.
Nat Commun
. 2024 Jul;
15(1):6374.
PMID: 39075067
Transcription-blocking DNA lesions are specifically targeted by transcription-coupled nucleotide excision repair (TC-NER), which removes a broad spectrum of DNA lesions to preserve transcriptional output and thereby cellular homeostasis to counteract...
5.
Giovannini S, Weibel L, Schittek B, Sinnberg T, Schaller M, Lemberg C, et al.
J Invest Dermatol
. 2024 Jul;
144(11):2465-2476.
PMID: 39047967
Phototoxicity and skin cancer are severe adverse effects of the anti-fungal drug voriconazole (VOR). These adverse effects resemble those seen in xeroderma pigmentosum, caused by defective DNA nucleotide excision repair...
6.
Muniesa-Vargas A, Davo-Martinez C, Ribeiro-Silva C, van der Woude M, Thijssen K, Haspels B, et al.
Nat Commun
. 2024 Apr;
15(1):3490.
PMID: 38664429
Congenital nucleotide excision repair (NER) deficiency gives rise to several cancer-prone and/or progeroid disorders. It is not understood how defects in the same DNA repair pathway cause different disease features...
7.
van Sluis M, Yu Q, van der Woude M, Gonzalo-Hansen C, Dealy S, Janssens R, et al.
Nat Cell Biol
. 2024 Apr;
26(5):770-783.
PMID: 38600236
DNA-protein crosslinks (DPCs) arise from enzymatic intermediates, metabolism or chemicals like chemotherapeutics. DPCs are highly cytotoxic as they impede DNA-based processes such as replication, which is counteracted through proteolysis-mediated DPC...
8.
Crossley M, Song C, Bocek M, Choi J, Kousouros J, Sathirachinda A, et al.
Nature
. 2024 Jan;
626(7998):E6.
PMID: 38263519
No abstract available.
9.
Slyskova J, Muniesa-Vargas A, Tojal Da Silva I, Drummond R, Park J, Hackes D, et al.
NAR Cancer
. 2023 Dec;
5(4):zcad057.
PMID: 38058548
The therapeutic efficacy of cisplatin and oxaliplatin depends on the balance between the DNA damage induction and the DNA damage response of tumor cells. Based on clinical evidence, oxaliplatin is...
10.
Schiffmacher D, Lee S, Kliza K, Theil A, Akita M, Helfricht A, et al.
Res Sq
. 2023 Oct;
PMID: 37886519
Transcription-blocking DNA lesions are specifically targeted by transcription-coupled nucleotide excision repair (TC-NER), which removes a broad spectrum of DNA lesions to preserve transcriptional output and thereby cellular homeostasis to counteract...