James W Simpkins
Overview
Explore the profile of James W Simpkins including associated specialties, affiliations and a list of published articles.
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Articles
172
Citations
4929
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Recent Articles
1.
Sarkar S, Corbin D, Simpkins J
Pharmaceuticals (Basel)
. 2024 Mar;
17(3).
PMID: 38543056
The bottleneck in drug discovery for central nervous system diseases is the absence of effective systemic drug delivery technology for delivering therapeutic drugs into the brain. Despite the advances in...
2.
Bumgarner J, Walker 2nd W, Quintana D, White R, Richmond A, Melendez-Fernandez O, et al.
iScience
. 2023 Aug;
26(7):106996.
PMID: 37534143
The structure and function of the cardiovascular system are modulated across the day by circadian rhythms, making this system susceptible to circadian rhythm disruption. Recent evidence demonstrated that short-term exposure...
3.
Quintana D, Anantula Y, Garcia J, Engler-Chiurazzi E, Sarkar S, Corbin D, et al.
Neurobiol Aging
. 2021 Jun;
105:115-128.
PMID: 34062487
Heart disease and vascular disease positively correlate with the incidence of Alzheimer's disease (AD). Although there is ostensible involvement of dysfunctional cerebrovasculature in AD pathophysiology, the characterization of the specific...
4.
Kim S, Russell A, Wang W, Gemoets D, Sarkar S, Simpkins J, et al.
J Neuroimmune Pharmacol
. 2021 May;
17(1-2):228-241.
PMID: 34028667
Alzheimer's disease (AD) and other neurodegenerative diseases are characterized by chronic neuroinflammation and a reduction in brain energy metabolism. An important role has emerged for small, non-coding RNA molecules known...
5.
Ren X, Hu H, Farooqi I, Simpkins J
Nat Commun
. 2021 May;
12(1):2957.
PMID: 33986263
No abstract available.
6.
Russell A, Cavendish J, Rai A, Vannoy M, Dakhlallah A, Hu H, et al.
ASN Neuro
. 2021 Feb;
13:1759091421991769.
PMID: 33626880
Globally, stroke is a leading cause of death and disability. Traditional risk factors like hypertension, diabetes, and obesity do not fully account for all stroke cases. Recent infection is regarded...
7.
Gao X, Boryczka J, Zheng P, Kasani S, Yang F, Engler-Chiurazzi E, et al.
Biosens Bioelectron
. 2021 Jan;
177:112967.
PMID: 33429202
Currently colorimetric paper lateral flow strips (PLFS) encounter two major limitations, that is, low sensitivity and severe interference from complex sample matrices such as blood. These shortcomings limit their application...
8.
Ren X, Hu H, Farooqi I, Simpkins J
Nat Commun
. 2020 Aug;
11(1):4078.
PMID: 32843630
Acute stroke causes complex, pathological, and systemic responses that have not been treatable by any single medication. In this study, using a murine transient middle cerebral artery occlusion stroke model,...
9.
Porter K, Sarkar S, Dakhlallah D, Vannoy M, Quintana D, Simpkins J
Front Aging Neurosci
. 2020 Apr;
12:92.
PMID: 32317959
Despite the extensive use of hormonal methods as either contraception or menopausal hormone therapy (HT), there is very little known about the potential effects of these compounds on the cellular...
10.
Sarvari S, Moakedi F, Hone E, Simpkins J, Ren X
Metab Brain Dis
. 2020 Apr;
35(6):851-868.
PMID: 32297170
Stroke is the leading cause of disability among adults as well as the 2nd leading cause of death globally. Ischemic stroke accounts for about 85% of strokes, and currently, tissue...