James W Puckett
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Explore the profile of James W Puckett including associated specialties, affiliations and a list of published articles.
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11
Citations
365
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Recent Articles
1.
Bzymek K, Puckett J, Zer C, Xie J, Ma Y, King J, et al.
Nat Commun
. 2018 Apr;
9(1):1580.
PMID: 29679060
Because monoclonal antibodies (mAbs) have exceptional specificity and favorable pharmacology, substantial efforts have been made to functionalize them, either with potent cytotoxins, biologics, radionuclides, or fluorescent groups for therapeutic benefit...
2.
Gerhardt J, Bhalla A, Butler J, Puckett J, Dervan P, Rosenwaks Z, et al.
Cell Rep
. 2016 Jul;
16(5):1218-1227.
PMID: 27425605
Friedreich's ataxia (FRDA) is caused by the expansion of GAA repeats located in the Frataxin (FXN) gene. The GAA repeats continue to expand in FRDA patients, aggravating symptoms and contributing...
3.
Raskatov J, Puckett J, Dervan P
Bioorg Med Chem
. 2014 May;
22(16):4371-5.
PMID: 24780272
In an effort to quantitate Py-Im polyamide concentrations in vivo, we synthesized the C-14 radioactively labeled compounds 1-3, and investigated their tumor localization in a subcutaneous xenograft model of prostate...
4.
Li B, Montgomery D, Puckett J, Dervan P
J Org Chem
. 2012 Oct;
78(1):124-33.
PMID: 23106218
Cyclic Py-Im polyamides containing two GABA turn units exhibit enhanced DNA binding affinity, but extensive studies of their biological properties have been hindered due to synthetic inaccessibility. A facile modular...
5.
Du J, Campau E, Soragni E, Ku S, Puckett J, Dervan P, et al.
J Biol Chem
. 2012 Jul;
287(35):29861-72.
PMID: 22798143
The genetic mutation in Friedreich ataxia (FRDA) is a hyperexpansion of the triplet-repeat sequence GAA·TTC within the first intron of the FXN gene. Although yeast and reporter construct models for...
6.
Puckett J, Green J, Dervan P
Org Lett
. 2012 May;
14(11):2774-7.
PMID: 22578091
Microwave synthesis was utilized to rapidly build Py-Im polyamides in high yields and purity using Boc-protection chemistry on Kaiser oxime resin. A representative polyamide targeting the 5'-WGWWCW-3' (W = A...
7.
Raskatov J, Meier J, Puckett J, Yang F, Ramakrishnan P, Dervan P
Proc Natl Acad Sci U S A
. 2011 Dec;
109(4):1023-8.
PMID: 22203967
Nuclear factor κB (NF-κB) is a transcription factor that regulates various aspects of immune response, cell death, and differentiation as well as cancer. In this study we introduce the Py-Im...
8.
Hsu C, Phillips J, Trauger J, Farkas M, Belitsky J, Heckel A, et al.
Tetrahedron
. 2008 Jul;
63(27):6146-6151.
PMID: 18596841
Hairpin pyrrole-imidazole (Py-Im) polyamides are programmable oligomers that bind the DNA minor groove in a sequence-specific manner with affinities comparable to those of natural DNA-binding proteins. These cell-permeable small molecules...
9.
Puckett J, Muzikar K, Tietjen J, Warren C, Ansari A, Dervan P
J Am Chem Soc
. 2007 Sep;
129(40):12310-9.
PMID: 17880081
A high-throughput Cognate Site Identity (CSI) microarray platform interrogating all 524 800 10-base pair variable sites is correlated to quantitative DNase I footprinting data of DNA binding pyrrole-imidazole polyamides. An...
10.
Burnett R, Melander C, Puckett J, Son L, Wells R, Dervan P, et al.
Proc Natl Acad Sci U S A
. 2006 Jul;
103(31):11497-502.
PMID: 16857735
The DNA abnormality found in 98% of Friedreich's ataxia (FRDA) patients is the unstable hyperexpansion of a GAA.TTC triplet repeat in the first intron of the frataxin gene. Expanded GAA.TTC...