James T Stivers
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Explore the profile of James T Stivers including associated specialties, affiliations and a list of published articles.
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90
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2337
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Recent Articles
1.
Egleston M, Bhat S, Howlader A, Bianchet M, Liu Y, Lopez Rovira L, et al.
Biochemistry
. 2025 Feb;
64(5):1109-1120.
PMID: 39989431
Sterile alpha motif histidine-aspartate domain protein 1 (SAMHD1) is an enzyme with diverse activities. Its dNTPase activity degrades all canonical dNTPs and many anticancer nucleoside drugs, while its single-stranded nucleic...
2.
Orris B, Sung M, Bhat S, Xu Y, Huynh K, Han S, et al.
Nucleic Acids Res
. 2023 Nov;
51(22):12443-12458.
PMID: 37930833
The dNTPase activity of tetrameric SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1) plays a critical role in cellular dNTP regulation. SAMHD1 also associates with stalled DNA replication...
3.
Guanine-containing ssDNA and RNA induce dimeric and tetrameric SAMHD1 in cryo-EM and binding studies
Orris B, Sung M, Bhat S, Xu Y, Huynh K, Han S, et al.
bioRxiv
. 2023 Jul;
PMID: 37398126
The dNTPase activity of tetrameric SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1) plays a critical role in cellular dNTP regulation. SAMHD1 also associates with stalled DNA replication...
4.
Egleston M, Dong L, Howlader A, Bhat S, Orris B, Bianchet M, et al.
ACS Chem Biol
. 2023 May;
18(10):2200-2210.
PMID: 37233733
Sterile alpha motif histidine-aspartate domain protein 1 (SAMHD1) is a deoxynucleotide triphosphohydrolase that exists in monomeric, dimeric, and tetrameric forms. It is activated by GTP binding to an A1 allosteric...
5.
Cui J, Meshesha M, Churgulia N, Merlo C, Fuchs E, Breakey J, et al.
Retrovirology
. 2022 Sep;
19(1):21.
PMID: 36114511
Background: Although CD4 memory T cells are considered the primary latent reservoir for HIV-1, replication competent HIV has been detected in tissue macrophages in both animal and human studies. During...
6.
Orris B, Huynh K, Ammirati M, Han S, Bolanos B, Carmody J, et al.
Nucleic Acids Res
. 2022 Jul;
50(13):7545-7559.
PMID: 35801923
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1) is driven into its activated tetramer form by binding of GTP activator and dNTP activators/substrates. In addition, the inactive monomeric...
7.
Christenson E, Gizzi A, Cui J, Egleston M, Seamon K, DePasquale M, et al.
Mol Pharmacol
. 2021 Apr;
99(6):412-425.
PMID: 33795350
Previous short-hairpin RNA knockdown studies have established that depletion of human uracil DNA glycosylase (hUNG) sensitizes some cell lines to 5-fluorodeoxyuridine (FdU). Here, we selectively inhibit the catalytic activity of...
8.
Meshesha M, Esadze A, Cui J, Churgulia N, Sahu S, Stivers J
PLoS One
. 2020 Jul;
15(7):e0235012.
PMID: 32663205
Non-dividing cells of the myeloid lineage such as monocytes and macrophages are target cells of HIV that have low dNTP pool concentrations and elevated levels of dUTP, which leads to...
9.
Rodriguez G, Orris B, Majumdar A, Bhat S, Stivers J
DNA Repair (Amst)
. 2019 Dec;
86:102764.
PMID: 31855846
Many human DNA repair proteins have disordered domains at their N- or C-termini with poorly defined biological functions. We recently reported that the partially structured N-terminal domain (NTD) of human...
10.
Cui J, Gizzi A, Stivers J
Nucleic Acids Res
. 2019 Mar;
47(8):4153-4168.
PMID: 30892639
dUTP is a close structural congener of dTTP and can be readily incorporated into DNA opposite to adenine during DNA replication leading to non-mutagenic dU/A base pairs ('uracilation'). We find...