James T Stivers
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Explore the profile of James T Stivers including associated specialties, affiliations and a list of published articles.
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90
Citations
2337
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Recent Articles
11.
Esadze A, Stivers J
Chem Rev
. 2018 Nov;
118(23):11298-11323.
PMID: 30379068
Preservation of the coding potential of the genome and highly regulated gene expression over the life span of a human are two fundamental requirements of life. These processes require the...
12.
Weiser B, Rodriguez G, Cole P, Stivers J
Nucleic Acids Res
. 2018 Jun;
46(14):7169-7178.
PMID: 29917162
The N-terminal domain (NTD) of nuclear human uracil DNA glycosylase (hUNG2) assists in targeting hUNG2 to replication forks through specific interactions with replication protein A (RPA). Here, we explored hUNG2...
13.
Esadze A, Rodriguez G, Weiser B, Cole P, Stivers J
Nucleic Acids Res
. 2017 Oct;
45(21):12413-12424.
PMID: 29036472
DNA 'sliding' by human repair enzymes is considered to be important for DNA damage detection. Here, we transfected uracil-containing DNA duplexes into human cells and measured the probability that nuclear...
14.
Rodriguez G, Esadze A, Weiser B, Schonhoft J, Cole P, Stivers J
ACS Chem Biol
. 2017 Aug;
12(9):2260-2263.
PMID: 28787572
Nuclear human uracil-DNA glycosylase (hUNG2) initiates base excision repair (BER) of genomic uracils generated through misincorporation of dUMP or through deamination of cytosines. Like many human DNA glycosylases, hUNG2 contains...
15.
Investigation of N-Terminal Phospho-Regulation of Uracil DNA Glycosylase Using Protein Semisynthesis
Weiser B, Stivers J, Cole P
Biophys J
. 2017 Jul;
113(2):393-401.
PMID: 28746850
Uracil DNA Glycosylase (UNG2) is the primary enzyme in humans that prevents the stable incorporation of deoxyuridine monophosphate into DNA in the form of U/A basepairs. During S-phase, UNG2 remains...
16.
Esadze A, Rodriguez G, Cravens S, Stivers J
Biochemistry
. 2017 Mar;
56(14):1974-1986.
PMID: 28345889
A major product of oxidative DNA damage is 8-oxoguanine. In humans, 8-oxoguanine DNA glycosylase (hOGG1) facilitates removal of these lesions, producing an abasic (AP) site in the DNA that is...
17.
Seamon K, Bumpus N, Stivers J
Biochemistry
. 2016 Oct;
55(44):6087-6099.
PMID: 27775344
Sterile alpha motif and HD domain protein 1 (SAMHD1) is a unique enzyme that plays important roles in nucleic acid metabolism, viral restriction, and the pathogenesis of autoimmune diseases and...
18.
Hansen E, Ransom M, Hesselberth J, Hosmane N, Capoferri A, Bruner K, et al.
Elife
. 2016 Sep;
5.
PMID: 27644592
We report that a major subpopulation of monocyte-derived macrophages (MDMs) contains high levels of dUTP, which is incorporated into HIV-1 DNA during reverse transcription (U/A pairs), resulting in pre-integration restriction...
19.
Cravens S, Stivers J
Biochemistry
. 2016 Aug;
55(37):5230-42.
PMID: 27571472
The energetic nature of the interactions of DNA base excision repair glycosylases with undamaged and damaged DNA and the nuclear environment are expected to significantly impact the time it takes...
20.
Seamon K, Sun Z, Shlyakhtenko L, Lyubchenko Y, Stivers J
Nucleic Acids Res
. 2015 Jun;
43(13):6486-99.
PMID: 26101257
The HIV-1 restriction factor SAMHD1 is a tetrameric enzyme activated by guanine nucleotides with dNTP triphosphate hydrolase activity (dNTPase). In addition to this established activity, there have been a series...