Joshua I Friedman
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Explore the profile of Joshua I Friedman including associated specialties, affiliations and a list of published articles.
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10
Citations
349
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Recent Articles
1.
Friedman J, Xia D, Regatte R, Jerschow A
J Magn Reson
. 2015 May;
256:43-51.
PMID: 25996515
Chemical Exchange Saturation Transfer (CEST) magnetic resonance experiments have become valuable tools in magnetic resonance for the detection of low concentration solutes with far greater sensitivity than direct detection methods....
2.
Friedman J, Li H, Monnat Jr R
Methods Mol Biol
. 2014 Feb;
1123:135-49.
PMID: 24510266
Homing endonucleases (HEs) are native proteins that recognize long DNA sequences with high site specificity in vitro and in vivo. The target site specificity of HEs is high, though not...
3.
Enzymatic excision of uracil residues in nucleosomes depends on the local DNA structure and dynamics
Ye Y, Stahley M, Xu J, Friedman J, Sun Y, McKnight J, et al.
Biochemistry
. 2012 Jul;
51(30):6028-38.
PMID: 22784353
The excision of uracil bases from DNA is accomplished by the enzyme uracil DNA glycosylase (UNG). Recognition of uracil bases in free DNA is facilitated by uracil base pair dynamics,...
4.
Lin C, Yadav N, Friedman J, Ratnakar J, Sherry A, van Zijl P
Magn Reson Med
. 2012 Jan;
67(4):906-11.
PMID: 22287162
Paramagnetic chemical exchange saturation transfer agents combine the benefits of a large chemical shift difference and a fast exchange rate for sensitive MRI detection. However, the in vivo detection of...
5.
Sun Y, Friedman J, Stivers J
Biochemistry
. 2011 Nov;
50(49):10724-31.
PMID: 22077282
The human DNA repair enzyme uracil DNA glycosylase (hUNG) locates and excises rare uracil bases that arise in DNA from cytosine deamination or through dUTP incorporation by DNA polymerases. Previous...
6.
Friedman J, Jiang Y, Miller P, Stivers J
Biochemistry
. 2010 Dec;
50(5):882-90.
PMID: 21174443
Bifunctional DNA alkylating agents form a diverse assortment of covalent DNA interstrand cross-linked (ICL) structures that are potent cytotoxins. Because it is implausible that cells could possess distinct DNA repair...
7.
Friedman J, Stivers J
Biochemistry
. 2010 May;
49(24):4957-67.
PMID: 20469926
A fundamental and shared process in all forms of life is the use of DNA glycosylase enzymes to excise rare damaged bases from genomic DNA. Without such enzymes, the highly...
8.
Friedman J, McMahon M, Stivers J, van Zijl P
J Am Chem Soc
. 2010 Jan;
132(6):1813-5.
PMID: 20095603
We report an "exchange-rate-filtered" magnetic resonance approach that allows the detection of exchangeable protons of low-concentration solutes without interference from nonexchanging protons. This indirect detection of signals of multiple rapidly...
9.
Friedman J, Majumdar A, Stivers J
Nucleic Acids Res
. 2009 Apr;
37(11):3493-500.
PMID: 19339520
The DNA repair enzyme human uracil DNA glycosylase (UNG) scans short stretches of genomic DNA and captures rare uracil bases as they transiently emerge from the DNA duplex via spontaneous...
10.
Parker J, Bianchet M, Krosky D, Friedman J, Amzel L, Stivers J
Nature
. 2007 Aug;
449(7161):433-7.
PMID: 17704764
The enzyme uracil DNA glycosylase (UNG) excises unwanted uracil bases in the genome using an extrahelical base recognition mechanism. Efficient removal of uracil is essential for prevention of C-to-T transition...