James T Slama
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Explore the profile of James T Slama including associated specialties, affiliations and a list of published articles.
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24
Citations
494
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Recent Articles
1.
Mu Q, Harris J, Yule D, Slama J, Marchant J, Patel S
Cell Calcium
. 2024 Nov;
124:102969.
PMID: 39579622
No abstract available.
2.
Zhang Y, Guan Z, Gadient J, Kumar S, Gunaratne G, Walseth T, et al.
ACS Chem Biol
. 2024 Aug;
19(8):1842-1849.
PMID: 39092791
Calcium ions (Ca) play a vital role as intracellular messengers, regulating essential cellular processes. Nicotinic acid adenine dinucleotide phosphate (NAADP) serves as a potent second messenger, responsible for releasing Ca...
3.
Gunaratne G, Kumar S, Lin-Moshier Y, Slama J, Brailoiu E, Patel S, et al.
J Biol Chem
. 2023 Oct;
299(12):105378.
PMID: 37866635
Membrane contact sites (MCSs) between endosomes and the endoplasmic reticulum (ER) are thought to act as specialized trigger zones for Ca signaling, where local Ca released via endolysosomal ion channels...
4.
Gunaratne G, Brailoiu E, Kumar S, Yuan Y, Slama J, Walseth T, et al.
Sci Signal
. 2023 Aug;
16(799):eadg0485.
PMID: 37607218
The second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) evokes calcium ion (Ca) release from endosomes and lysosomes by activating two-pore channels (TPCs) on these organelles. Rather than directly binding...
5.
Andy D, Gunaratne G, Marchant J, Walseth T, Slama J
Bioorg Med Chem
. 2022 Nov;
76:117099.
PMID: 36446271
A photo-clickable analog of adenosine was devised and synthesized in which the photoactive functional group (8-azidoadenosine) and the click moiety (2'-O-propargyl-ether) were compactly combined within the structure of the adenosine...
6.
Marchant J, Gunaratne G, Cai X, Slama J, Patel S
Trends Biochem Sci
. 2021 Nov;
47(3):235-249.
PMID: 34810081
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that releases Ca from endosomes and lysosomes by activating ion channels called two-pore channels (TPCs). However, no NAADP-binding site has...
7.
Gunaratne G, Brailoiu E, He S, Unterwald E, Patel S, Slama J, et al.
Sci Signal
. 2021 Mar;
14(675).
PMID: 33758061
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that releases Ca from acidic organelles through the activation of two-pore channels (TPCs) to regulate endolysosomal trafficking events. NAADP action...
8.
Su P, Bretz J, Gunaratne G, Marchant J, Walseth T, Slama J
Bioorg Med Chem
. 2020 Dec;
30:115901.
PMID: 33321420
Nicotinamide adenine dinucleotide phosphate (NADP) is an indispensable metabolic co-substrate and nicotinic acid adenine dinucleotide phosphate (NAADP) is an important Ca releasing intracellular second messenger. Exploration of the NADP and...
9.
Asfaha T, Gunaratne G, Johns M, Marchant J, Walseth T, Slama J
Cell Calcium
. 2019 Aug;
83:102060.
PMID: 31442840
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca mobilizing second messenger which triggers Ca release in both sea urchin egg homogenates and in mammalian cells. The NAADP binding...
10.
Gunaratne G, Su P, Marchant J, Slama J, Walseth T
Biochim Biophys Acta Mol Cell Res
. 2018 Dec;
1866(7):1180-1188.
PMID: 30521871
Nicotinic acid adenine dinucleotide phosphate is an evolutionarily conserved second messenger, which mobilizes Ca from acidic stores. The molecular identity of the NAADP receptor has yet to be defined. In...