Thomas U Schwartz
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Explore the profile of Thomas U Schwartz including associated specialties, affiliations and a list of published articles.
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66
Citations
3410
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Recent Articles
1.
Kafantari E, Hernandez V, Necpal J, Leonidou M, Baureder R, Hedberg-Oldfors C, et al.
Parkinsonism Relat Disord
. 2025 Mar;
134:107781.
PMID: 40088780
Dystonia is a movement disorder characterized by genetic and clinical heterogeneity. A recurring p.(Glu303del)-deletion in TOR1A is a well-established cause for DYT-TOR1A (DYT1), an autosomal dominant early-onset isolated dystonia. TOR1A...
2.
Fu L, Weiskopf E, Akkermans O, Swanson N, Cheng S, Schwartz T, et al.
Nature
. 2024 Jan;
626(8000):843-851.
PMID: 38267583
HIV-1 infection requires nuclear entry of the viral genome. Previous evidence suggests that this entry proceeds through nuclear pore complexes (NPCs), with the 120 × 60 nm capsid squeezing through...
3.
Antoku S, Schwartz T, Gundersen G
Front Cell Dev Biol
. 2023 May;
11:1160219.
PMID: 37215084
In this review, we discuss FHOD formins with a focus on recent studies that reveal a new role for them as critical links for nuclear mechanotransduction. The FHOD family in...
4.
Swofford C, Nordeen S, Chen L, Desai M, Chen J, Springs S, et al.
Protein Sci
. 2022 Sep;
31(11):e4457.
PMID: 36153664
Antibiotics in aquaculture prevent bacterial infection of fish, but their misuse is a public health risk and contributes to the unintentional creation of multiresistant pathogens. Regulatory agencies cannot do the...
5.
Schwartz T
Science
. 2022 Jun;
376(6598):1158-1159.
PMID: 35679398
Using a battery of tools, the architecture of the nuclear pore complex is revealed.
6.
K Singh R, Soliman A, Guaitoli G, Stormer E, von Zweydorf F, Dal Maso T, et al.
Proc Natl Acad Sci U S A
. 2022 Feb;
119(9).
PMID: 35217606
Mutations in the gene coding for leucine-rich repeat kinase 2 (LRRK2) are a leading cause of the inherited form of Parkinson's disease (PD), while LRRK2 overactivation is also associated with...
7.
Schuller A, Wojtynek M, Mankus D, Tatli M, Kronenberg-Tenga R, Regmi S, et al.
Nature
. 2021 Oct;
598(7882):667-671.
PMID: 34646014
Nuclear pore complexes (NPCs) create large conduits for cargo transport between the nucleus and cytoplasm across the nuclear envelope (NE). These multi-megadalton structures are composed of about thirty different nucleoporins...
8.
Lim S, Cruz V, Antoku S, Gundersen G, Schwartz T
Structure
. 2021 Jan;
29(6):540-552.e5.
PMID: 33472039
The nuclear position in eukaryotes is controlled by a nucleo-cytoskeletal network, critical in cell differentiation, division, and movement. Forces are transmitted through conserved Linker of Nucleoskeleton and Cytoskeleton (LINC) complexes...
9.
Nordeen S, Andersen K, Knockenhauer K, Ingram J, Ploegh H, Schwartz T
Nat Commun
. 2020 Dec;
11(1):6179.
PMID: 33268786
Nuclear pore complexes (NPCs) are the main conduits for molecular exchange across the nuclear envelope. The NPC is a modular assembly of ~500 individual proteins, called nucleoporins or nups. Most...
10.
Nordeen S, Turman D, Schwartz T
Nat Commun
. 2020 Nov;
11(1):6060.
PMID: 33247142
The hallmark of the eukaryotic cell is the complex endomembrane system that compartmentalizes cellular functions. Transport into and out of the nucleus occurs through the nuclear pore complex (NPC). The...