Beeke Wienert
Overview
Explore the profile of Beeke Wienert including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
865
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Recent Articles
1.
Wallace K, Gerstenberg T, Ennis C, Perez-Bermejo J, Partridge J, Bandoro C, et al.
Mol Ther
. 2025 Mar;
PMID: 40022449
β-Hemoglobinopathies are common monogenic disorders. In sickle cell disease (SCD), a single mutation in the β-globin (HBB) gene results in dysfunctional hemoglobin protein, while in β-thalassemia, over 300 mutations distributed...
2.
Chu S, Soupene E, Sharma D, Sinha R, McCreary T, Hernandez B, et al.
Cell Rep
. 2025 Jan;
44(1):115141.
PMID: 39754719
The most severe form of α-thalassemia results from loss of all four copies of α-globin. Postnatally, patients face challenges similar to β-thalassemia, including severe anemia and erythrotoxicity due to the...
3.
Chu S, Soupene E, Wienert B, Yin H, Sharma D, McCreary T, et al.
bioRxiv
. 2024 May;
PMID: 38766216
Alpha-thalassemia is an autosomal recessive disease with increasing worldwide prevalence. The molecular basis is due to mutation or deletion of one or more duplicated α-globin genes, and disease severity is...
4.
Perez-Bermejo J, Efagene O, Matern W, Holden J, Kabir S, Chew G, et al.
Nat Commun
. 2024 Mar;
15(1):2625.
PMID: 38521763
Homology Directed Repair (HDR) enables precise genome editing, but the implementation of HDR-based therapies is hindered by limited efficiency in comparison to methods that exploit alternative DNA repair routes, such...
5.
Wienert B, Cromer M
Front Genome Ed
. 2023 Feb;
4:1112956.
PMID: 36742457
[This corrects the article DOI: 10.3389/fgeed.2022.1050507.].
6.
Wienert B, Cromer M
Front Genome Ed
. 2022 Nov;
4:1050507.
PMID: 36439866
The discovery of CRISPR has allowed site-specific genomic modification to become a reality and this technology is now being applied in a number of human clinical trials. While this technology...
7.
Ravi N, Wienert B, Wyman S, Bell H, George A, Mahalingam G, et al.
Elife
. 2022 Feb;
11.
PMID: 35147495
Naturally occurring point mutations in the promoter switch hemoglobin synthesis from defective adult beta-globin to fetal gamma-globin in sickle cell patients with hereditary persistence of fetal hemoglobin (HPFH) and ameliorate...
8.
Wienert B, Nguyen D, Guenther A, Feng S, Locke M, Wyman S, et al.
Nat Commun
. 2020 May;
11(1):2109.
PMID: 32355159
Repair of double strand DNA breaks (DSBs) can result in gene disruption or gene modification via homology directed repair (HDR) from donor DNA. Altering cellular responses to DSBs may rebalance...
9.
Wienert B, Wyman S, Yeh C, Conklin B, Corn J
Nat Protoc
. 2020 Apr;
15(5):1775-1799.
PMID: 32313254
DISCOVER-seq (discovery of in situ Cas off-targets and verification by sequencing) is a broadly applicable approach for unbiased CRISPR-Cas off-target identification in cells and tissues. It leverages the recruitment of...
10.
Wienert B, Wyman S, Richardson C, Yeh C, Akcakaya P, Porritt M, et al.
Science
. 2019 Apr;
364(6437):286-289.
PMID: 31000663
CRISPR-Cas genome editing induces targeted DNA damage but can also affect off-target sites. Current off-target discovery methods work using purified DNA or specific cellular models but are incapable of direct...