James L Stevens
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Explore the profile of James L Stevens including associated specialties, affiliations and a list of published articles.
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28
Citations
691
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Recent Articles
11.
Copple I, den Hollander W, Callegaro G, Mutter F, Maggs J, Schofield A, et al.
Arch Toxicol
. 2018 Nov;
93(2):385-399.
PMID: 30426165
The transcription factor NRF2, governed by its repressor KEAP1, protects cells against oxidative stress. There is interest in modelling the NRF2 response to improve the prediction of clinical toxicities such...
12.
Willy J, Young S, Mosley A, Gawrieh S, Stevens J, Masuoka H, et al.
J Biol Chem
. 2017 Jul;
292(34):14050-14065.
PMID: 28710282
Nonalcoholic fatty liver disease (steatosis) is the most prevalent liver disease in the Western world. One of the advanced pathologies is nonalcoholic steatohepatitis (NASH), which is associated with induction of...
13.
Weaver R, Betts C, Blomme E, Gerets H, Jensen K, Hewitt P, et al.
Expert Opin Drug Metab Toxicol
. 2017 Jun;
13(7):767-782.
PMID: 28604124
The liver is an important target for drug-induced toxicities. Early detection of hepatotoxic drugs requires use of well-characterized test systems, yet current knowledge, gaps and limitations of tests employed remains...
14.
Sutherland J, Jolly R, Goldstein K, Stevens J
PLoS Comput Biol
. 2016 Mar;
12(3):e1004847.
PMID: 27028627
The effect of drugs, disease and other perturbations on mRNA levels are studied using gene expression microarrays or RNA-seq, with the goal of understanding molecular effects arising from the perturbation....
15.
Willy J, Young S, Stevens J, Masuoka H, Wek R
Mol Biol Cell
. 2015 Apr;
26(12):2190-204.
PMID: 25904325
Free fatty acid induction of inflammation and cell death is an important feature of nonalcoholic steatohepatitis (NASH) and has been associated with disruption of the endoplasmic reticulum and activation of...
16.
Andersen M, Betts K, Dragan Y, Fitzpatrick S, Goodman J, Hartung T, et al.
ALTEX
. 2014 Jul;
31(3):364-7.
PMID: 25061900
No abstract available.
17.
Lafleur M, Stevens J, Lawrence J
Toxicol Pathol
. 2013 Jan;
41(2):235-62.
PMID: 23334697
The proper folding, assembly, and maintenance of cellular proteins is a highly regulated process and is critical for cellular homeostasis. Multiple cellular compartments have adapted their own systems to ensure...
18.
Sutherland J, Raymond J, Stevens J, Baker T, Watson D
J Med Chem
. 2012 Jun;
55(14):6455-66.
PMID: 22716080
A primary goal of lead optimization is to identify compounds with improved absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties. A number of reports have linked computed molecular properties to...
19.
Bonnefoi M, Belanger S, Devlin D, Doerrer N, Embry M, Fukushima S, et al.
Crit Rev Toxicol
. 2010 Sep;
40(10):893-911.
PMID: 20854192
The public health and environmental communities will face many challenges during the next decade. To identify significant issues that might be addressed as part of the International Life Sciences Institute...
20.
Bercu J, Jolly R, Flagella K, Baker T, Romero P, Stevens J
Regul Toxicol Pharmacol
. 2010 Aug;
58(3):369-81.
PMID: 20801182
In order to determine a threshold for nongenotoxic carcinogens, the traditional risk assessment approach has been to identify a mode of action (MOA) with a nonlinear dose-response. The dose-response for...