Steven J Kunnen
Overview
Explore the profile of Steven J Kunnen including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
278
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0
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Recent Articles
1.
Wijaya L, Kunnen S, Trairatphisan P, Fisher C, Crosby M, Schaefer K, et al.
Cell Biol Toxicol
. 2025 Feb;
41(1):49.
PMID: 39982567
Nephrotoxicity caused by drug or chemical exposure involves complex mechanisms as well as a temporal integration of injury and repair responses in different nephron segments. Distinct cellular transcriptional programs regulate...
2.
Meijer T, Ter Braak B, Loonstra-Wolters L, Kunnen S, Islam B, Suciu I, et al.
Toxicol In Vitro
. 2025 Feb;
104:106010.
PMID: 39900124
The potent dihydroorotate dehydrogenase (DHODH) inhibitor brequinar has been investigated as an anticancer, immunosuppressive, and antiviral pharmaceutical agent. However, its toxicity is still poorly understood. We investigated the cellular responses...
3.
Kunnen S, Arnesdotter E, Willenbockel C, Vinken M, van de Water B
ALTEX
. 2024 Feb;
41(2):213-232.
PMID: 38376873
Next generation risk assessment of chemicals revolves around the use of mechanistic information without animal experimentation. In this regard, toxicogenomics has proven to be a useful tool to elucidate the...
4.
Russomanno G, Sison-Young R, Livoti L, Coghlan H, Jenkins R, Kunnen S, et al.
Toxicol Sci
. 2023 Aug;
196(1):112-125.
PMID: 37647630
To minimize the occurrence of unexpected toxicities in early phase preclinical studies of new drugs, it is vital to understand fundamental similarities and differences between preclinical species and humans. Species...
5.
Callegaro G, Schimming J, Pinero Gonzalez J, Kunnen S, Wijaya L, Trairatphisan P, et al.
iScience
. 2023 Mar;
26(3):106094.
PMID: 36895646
Animal testing is the current standard for drug and chemicals safety assessment, but hazards translation to human is uncertain. Human models can address the species translation but might not replicate...
6.
Vrijenhoek N, Wehr M, Kunnen S, Wijaya L, Callegaro G, Mone M, et al.
ALTEX
. 2022 Jan;
39(2):207–220.
PMID: 35040482
Chemical read-across is commonly evaluated without specific knowledge of the biological mechanisms leading to observed adverse outcomes in vivo. Integrating data that indicate shared modes of action in humans will...
7.
Callegaro G, Kunnen S, Trairatphisan P, Grosdidier S, Niemeijer M, den Hollander W, et al.
Arch Toxicol
. 2021 Oct;
95(12):3745-3775.
PMID: 34626214
Mechanism-based risk assessment is urged to advance and fully permeate into current safety assessment practices, possibly at early phases of drug safety testing. Toxicogenomics is a promising source of mechanisms-revealing...
8.
Aguirre-Plans J, Pinero J, Souza T, Callegaro G, Kunnen S, Sanz F, et al.
Biol Direct
. 2021 Jan;
16(1):5.
PMID: 33435983
Background: Drug-induced liver injury (DILI) is an adverse reaction caused by the intake of drugs of common use that produces liver damage. The impact of DILI is estimated to affect...
9.
Kunnen S, Malas T, Formica C, Leonhard W, t Hoen P, Peters D
Biomed Pharmacother
. 2018 Oct;
108:1123-1134.
PMID: 30372813
Mutations in the PKD1 or PKD2 genes are the cause of autosomal dominant polycystic kidney disease (ADPKD). The encoded proteins localize within the cell membrane and primary cilia and are...
10.
Kunnen S, Malas T, Semeins C, Bakker A, Peters D
J Cell Physiol
. 2017 Oct;
233(4):3615-3628.
PMID: 29044509
Renal epithelial cells are exposed to mechanical forces due to flow-induced shear stress within the nephrons. Shear stress is altered in renal diseases caused by tubular dilation, obstruction, and hyperfiltration,...