James L Hougland
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Explore the profile of James L Hougland including associated specialties, affiliations and a list of published articles.
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47
Citations
522
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Recent Articles
1.
Hossain M, Alam M, Huang Z, Mousazadeh F, Sarangi R, de Jong E, et al.
Bioconjug Chem
. 2025 Mar;
PMID: 40029010
Geranylgeranylation is a critical post-translational modification essential for various cellular functions. However, current methods for synthesizing geranylgeranylated proteins are complex and costly, which hinders access to these proteins for both...
2.
Ford A, Taft C, Sprague-Getsy A, Carlson G, Mate N, Sieburg M, et al.
Biomolecules
. 2025 Feb;
15(2).
PMID: 40001510
Ghrelin is a 28 amino acid peptide hormone that impacts a wide range of biological processes, including appetite regulation, glucose metabolism, growth hormone regulation, and cognitive function. To bind and...
3.
Auger S, Pedersen J, Maity S, Sprague-Getsy A, Lorimer E, Koehn O, et al.
Biochemistry
. 2024 Dec;
64(1):138-155.
PMID: 39652878
Prenylation consists of the modification of proteins with either farnesyl diphosphate (FPP) or geranylgeranyl diphosphate (GGPP) at a cysteine near the C-terminus of target proteins to generate thioether-linked lipidated proteins....
4.
Schey G, Hildebrandt E, Wang Y, Diwan S, Passetti H, Potts G, et al.
Int J Mol Sci
. 2024 May;
25(10).
PMID: 38791363
Protein farnesylation is a post-translational modification where a 15-carbon farnesyl isoprenoid is appended to the C-terminal end of a protein by farnesyltransferase (FTase). This process often causes proteins to associate...
5.
Hildebrandt E, Hussain S, Sieburg M, Ravishankar R, Asad N, Gore S, et al.
Bioorg Chem
. 2024 Apr;
147:107316.
PMID: 38583246
Ras GTPases and other CaaX proteins undergo multiple post-translational modifications at their carboxyl-terminus. These events initiate with prenylation of a cysteine and are followed by endoproteolytic removal of the 'aaX'...
6.
Pierce M, Ji J, Novak S, Sieburg M, Nangia S, Nangia S, et al.
J Chem Inf Model
. 2023 Nov;
63(22):7159-7170.
PMID: 37939203
Membrane proteins are difficult to isolate and purify due to their dependence on the surrounding lipid membrane for structural stability. Detergents are often used to solubilize these proteins, with this...
7.
Justyna K, Das R, Lorimer E, Hu J, Pedersen J, Sprague-Getsy A, et al.
Org Lett
. 2023 Sep;
25(36):6767-6772.
PMID: 37669435
Prenylated proteins contain C or C isoprenoids linked to cysteine residues positioned near their C-termini. Here we describe the preparation of isoprenoid diphosphate analogues incorporating diazirine groups that can be...
8.
Campana M, Davis T, Novak S, Cleverdon E, Bates M, Krishnan N, et al.
ACS Chem Biol
. 2023 Jul;
18(8):1880-1890.
PMID: 37494676
Ghrelin acyltransferase (GOAT) plays a central role in the maturation and activation of the peptide hormone ghrelin, which performs a wide range of endocrinological signaling roles. Using a tight-binding fluorescent...
9.
Pierce M, Hougland J
Front Physiol
. 2023 May;
14:1167873.
PMID: 37250116
Acylation modifications play a central role in biological and physiological processes. Across a range of biomolecules from phospholipids to triglycerides to proteins, introduction of a hydrophobic acyl chain can dramatically...
10.
Deschaine S, Hedegaard M, Pince C, Farokhnia M, Moose J, Stock I, et al.
J Pharmacol Exp Ther
. 2023 Jan;
386(2):117-128.
PMID: 36631279
Preclinical and clinical studies have identified the ghrelin receptor [growth hormone secretagogue receptor (GHSR)1a] as a potential target for treating alcohol use disorder. A recent phase 1a clinical trial of...