James Eisenbart
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Explore the profile of James Eisenbart including associated specialties, affiliations and a list of published articles.
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10
Citations
1116
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Recent Articles
1.
Jain M, Rivera S, Monclus E, Synenki L, Zirk A, Eisenbart J, et al.
J Biol Chem
. 2012 Dec;
288(2):770-7.
PMID: 23204521
TGF-β signaling is required for normal tissue repair; however, excessive TGF-β signaling can lead to robust profibrotic gene expression in fibroblasts, resulting in tissue fibrosis. TGF-β binds to cell-surface receptors,...
2.
Tormos K, Anso E, Hamanaka R, Eisenbart J, Joseph J, Kalyanaraman B, et al.
Cell Metab
. 2011 Oct;
14(4):537-44.
PMID: 21982713
Adipocyte differentiation is characterized by an increase in mitochondrial metabolism. However, it is not known whether the increase in mitochondrial metabolism is essential for differentiation or a byproduct of the...
3.
Budinger G, Mutlu G, Urich D, Soberanes S, Buccellato L, Hawkins K, et al.
Am J Respir Crit Care Med
. 2010 Oct;
183(8):1043-54.
PMID: 20959557
Rationale: Acute lung injury and the acute respiratory distress syndrome are characterized by increased lung oxidant stress and apoptotic cell death. The contribution of epithelial cell apoptosis to the development...
4.
Chandel N, Budinger G, Mutlu G, Varga J, Synenki L, Donnelly H, et al.
Crit Care Med
. 2009 Mar;
37(5):1678-84.
PMID: 19325470
Objective: Keratinocyte growth factor (KGF) is expressed primarily by fibroblasts, is important for alveolar epithelial proliferation/function, and protects against lung injury in multiple animal models. We wished to determine whether...
5.
Bell E, Klimova T, Eisenbart J, Schumacker P, Chandel N
Mol Cell Biol
. 2007 Jun;
27(16):5737-45.
PMID: 17562866
Physiological hypoxia extends the replicative life span of human cells in culture. Here, we report that hypoxic extension of replicative life span is associated with an increase in mitochondrial reactive...
6.
Bell E, Klimova T, Eisenbart J, Moraes C, Murphy M, Budinger G, et al.
J Cell Biol
. 2007 Jun;
177(6):1029-36.
PMID: 17562787
Mammalian cells increase transcription of genes for adaptation to hypoxia through the stabilization of hypoxia-inducible factor 1alpha (HIF-1alpha) protein. How cells transduce hypoxic signals to stabilize the HIF-1alpha protein remains...
7.
Synenki L, Chandel N, Budinger G, Donnelly H, Topin J, Eisenbart J, et al.
Crit Care Med
. 2007 Jan;
35(3):842-8.
PMID: 17255860
Objective: Myofibroblasts express alpha-smooth muscle actin (alphaSMA), are important in tissue repair, and are present in the early phase of acute lung injury/acute respiratory distress syndrome (ALI/ARDS). We wished to...
8.
Budinger G, Mutlu G, Eisenbart J, Fuller A, Bellmeyer A, Baker C, et al.
Proc Natl Acad Sci U S A
. 2006 Mar;
103(12):4604-9.
PMID: 16537427
The molecular mechanisms of pulmonary fibrosis are poorly understood. Previous reports indicate that activation of TGF-beta1 is essential for the development of pulmonary fibrosis. Here, we report that the proapoptotic...
9.
Lee V, Schroedl C, Brunelle J, Buccellato L, Akinci O, Kaneto H, et al.
Am J Physiol Lung Cell Mol Physiol
. 2005 Sep;
289(4):L521-8.
PMID: 16148050
Exposure to bleomycin in rodents induces lung injury and fibrosis. Alveolar epithelial cell death has been hypothesized as an initiating mechanism underlying bleomycin-induced lung injury and fibrosis. In the present...
10.
Budinger G, Chandel N, Donnelly H, Eisenbart J, Oberoi M, Jain M
Intensive Care Med
. 2004 Nov;
31(1):121-8.
PMID: 15565360
Objective: Fibroproliferation markers like procollagen I predict mortality in patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). We sought to determine whether bronchoalveolar lavage fluid (BALF)...