James E Miskin
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Explore the profile of James E Miskin including associated specialties, affiliations and a list of published articles.
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7
Citations
158
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Recent Articles
1.
Farley D, McCloskey L, Thorne B, Tareen S, Nicolai C, Campbell D, et al.
Mol Ther Methods Clin Dev
. 2015 Jun;
2:15017.
PMID: 26029728
It is a current regulatory requirement to demonstrate absence of detectable replication-competent lentivirus (RCL) in lentiviral vector products prior to use in clinical trials. Immune Design previously described an HIV-1-based...
2.
Farley D, Bannister R, Leroux-Carlucci M, Evans N, Miskin J, Mitrophanous K
Hum Gene Ther Methods
. 2012 Nov;
23(5):309-23.
PMID: 23121195
The release of lentiviral vectors for clinical use requires the testing of vector material, production cells, and, if applicable, ex vivo-transduced cells for the presence of replication-competent lentivirus (RCL). Vectors...
3.
Jarraya B, Boulet S, Ralph G, Jan C, Bonvento G, Azzouz M, et al.
Sci Transl Med
. 2010 Apr;
1(2):2ra4.
PMID: 20368163
In Parkinson's disease, degeneration of specific neurons in the midbrain can cause severe motor deficits, including tremors and the inability to initiate movement. The standard treatment is administration of pharmacological...
4.
Farley D, Iqball S, Smith J, Miskin J, Kingsman S, Mitrophanous K
J Gene Med
. 2007 Mar;
9(5):345-56.
PMID: 17366519
Pseudotyping viral vectors with vesicular stomatitis virus glycoprotein (VSV-G) enables the transduction of an extensive range of cell types from different species. We have discovered two important parameters of the...
5.
Hacker C, Vink C, Wardell T, Lee S, Treasure P, Kingsman S, et al.
Mol Ther
. 2006 Sep;
14(4):536-45.
PMID: 16950499
Lentiviral vectors based on equine infectious anemia virus (EIAV) stably integrate into dividing and nondividing cells such as neurons, conferring long-term expression of their transgene. The integration profile of an...
6.
Goatley L, Twigg S, Miskin J, Monaghan P, St-Arnaud R, Smith G, et al.
J Virol
. 2002 Sep;
76(19):9991-9.
PMID: 12208975
The African swine fever virus (ASFV) j4R protein is expressed late during the virus replication cycle and is present in both the nucleus and the cytoplasm of infected cells. By...
7.
Miskin J, Farrell A, Cunliffe W, Holland K
Microbiology (Reading)
. 1997 May;
143 ( Pt 5):1745-1755.
PMID: 9168624
Five independent clones of the Propionibacterium acnes P-37 lipase gene (gehA) were obtained in Escherichia coli, and the gene was localized to a 2.75 kb Xhol fragment by subcloning. The...