Kyriacos A Mitrophanous
Overview
Explore the profile of Kyriacos A Mitrophanous including associated specialties, affiliations and a list of published articles.
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34
Citations
1665
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Recent Articles
1.
Iqball S, Beck D, Devarajan G, Khoo C, OConnor D, Ellis S, et al.
Mol Ther Methods Clin Dev
. 2023 Aug;
30:350-366.
PMID: 37637380
Neovascular age-related macular degeneration (nAMD) is a leading cause of blindness in the aging population, with vascular endothelial growth factor (VEGF) playing a key role. Treatment with recombinant anti-VEGFs is...
2.
Badin R, Binley K, Van Camp N, Jan C, Gourlay J, Robert C, et al.
Mol Ther Methods Clin Dev
. 2019 Aug;
14:206-216.
PMID: 31406701
A recent phase I-II, open-label trial of ProSavin, a lentiviral vector delivering the key enzymes in the dopamine biosynthetic pathway to non-dopaminergic striatal neurons, demonstrated safety and improved motor function...
3.
Palfi S, Gurruchaga J, Lepetit H, Howard K, Ralph G, Mason S, et al.
Hum Gene Ther Clin Dev
. 2018 Aug;
29(3):148-155.
PMID: 30156440
Parkinson's disease is typically treated with oral dopamine replacement therapies. However, long-term use is complicated by motor fluctuations from intermittent stimulation of dopamine receptors and off-target effects. ProSavin, a lentiviral...
4.
Fouladi N, Parker M, Kennedy V, Binley K, McCloskey L, Loader J, et al.
Hum Gene Ther
. 2018 Jan;
29(6):687-698.
PMID: 29361840
Due to both the avascularity of the cornea and the relatively immune-privileged status of the eye, corneal transplantation is one of the most successful clinical transplant procedures. However, in high-risk...
5.
Barker G, Banks P, Scott H, Ralph G, Mitrophanous K, Wong L, et al.
Nat Neurosci
. 2017 Jan;
20(2):242-250.
PMID: 28067902
Episodic memory formation depends on information about a stimulus being integrated within a precise spatial and temporal context, a process dependent on the hippocampus and prefrontal cortex. Investigations of putative...
6.
Campochiaro P, Lauer A, Sohn E, Mir T, Naylor S, Anderton M, et al.
Hum Gene Ther
. 2016 Oct;
28(1):99-111.
PMID: 27710144
Neovascular age-related macular degeneration (NVAMD) is a prevalent cause of vision loss. Intraocular injections of VEGF-neutralizing proteins provide benefit, but many patients require frequent injections for a prolonged period. Benefits...
7.
Stewart H, Ralph G, Fong-Wong L, Strickland I, McCloskey L, Barnes L, et al.
Hum Gene Ther Clin Dev
. 2016 Jul;
27(3):100-10.
PMID: 27470285
Pharmacological dopamine replacement therapies provide the most well-established treatments for Parkinson's disease (PD). However, these long-term treatments can lead to motor complications and off-target effects. ProSavin(®), a lentiviral vector (LV)-based...
8.
Farley D, McCloskey L, Thorne B, Tareen S, Nicolai C, Campbell D, et al.
Mol Ther Methods Clin Dev
. 2015 Jun;
2:15017.
PMID: 26029728
It is a current regulatory requirement to demonstrate absence of detectable replication-competent lentivirus (RCL) in lentiviral vector products prior to use in clinical trials. Immune Design previously described an HIV-1-based...
9.
Zallocchi M, Binley K, Lad Y, Ellis S, Widdowson P, Iqball S, et al.
PLoS One
. 2014 Apr;
9(4):e94272.
PMID: 24705452
Usher syndrome type 1B is a combined deaf-blindness condition caused by mutations in the MYO7A gene. Loss of functional myosin VIIa in the retinal pigment epithelia (RPE) and/or photoreceptors leads...
10.
Parker M, Bellec J, McFarland T, Scripps V, Appukuttan B, Hartzell M, et al.
Hum Gene Ther
. 2014 Jan;
25(5):408-18.
PMID: 24460027
Corneal transplantation is the oldest and one of the most successful transplant procedures with a success rate in many studies in excess of 90%. The high success rate is mainly...