James E Gomez
Overview
Explore the profile of James E Gomez including associated specialties, affiliations and a list of published articles.
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14
Citations
643
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Recent Articles
1.
Khandelwal N, Gupta M, Gomez J, Barkho S, Guan Z, Eng A, et al.
bioRxiv
. 2024 Sep;
PMID: 39282303
A broad chemical genetics screen in to identify inhibitors of established or previously untapped targets for therapeutic development yielded compounds (BRD-8000.3 and BRD-9327) that inhibit the essential efflux pump EfpA....
2.
Sturm A, Sun P, Avila-Pacheco J, Clatworthy A, Bloom-Ackermann Z, Wuo M, et al.
mBio
. 2024 Jan;
15(2):e0320823.
PMID: 38236034
(Mtb) can adopt a non-growing dormant state during infection that may be critical to both active and latent tuberculosis. During dormancy, Mtb is widely tolerant toward antibiotics, a significant obstacle...
3.
Di Germanio C, Simmons G, Kelly K, Martinelli R, Darst O, Azimpouran M, et al.
Transfusion
. 2021 Jun;
61(9):2677-2687.
PMID: 34121205
Background: Antibody response duration following severe acute respiratory syndrome coronavirus 2 infection tends to be variable and depends on severity of disease and method of detection. Study Design And Methods:...
4.
Johnson E, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, et al.
Nature
. 2019 Jun;
571(7763):72-78.
PMID: 31217586
New antibiotics are needed to combat rising levels of resistance, with new Mycobacterium tuberculosis (Mtb) drugs having the highest priority. However, conventional whole-cell and biochemical antibiotic screens have failed. Here...
5.
Fang C, Lee K, Nietupski R, Bates R, Fernandez-Menendez R, Lopez-Roman E, et al.
Bioorg Med Chem Lett
. 2018 Oct;
28(22):3529-3533.
PMID: 30316633
Previous work established a coumarin scaffold as a starting point for inhibition of Mycobacterium tuberculosis (Mtb) FadD32 enzymatic activity. After further profiling of the coumarin inhibitor 4 revealed chemical instability,...
6.
Gomez J, Kaufmann-Malaga B, Wivagg C, Kim P, Silvis M, Renedo N, et al.
Elife
. 2017 Feb;
6.
PMID: 28220755
Antibiotic resistance arising via chromosomal mutations is typically specific to a particular antibiotic or class of antibiotics. We have identified mutations in genes encoding ribosomal components in that confer resistance...
7.
Wivagg C, Wellington S, Gomez J, Hung D
ACS Infect Dis
. 2016 Sep;
2(2):104-10.
PMID: 27624961
Recent studies have renewed interest in β-lactam antibiotics as a potential treatment for Mycobacterium tuberculosis infection. To explore the opportunities and limitations of this approach, we sought to better understand...
8.
Zhang D, Gomez J, Chien J, Haseley N, Desjardins C, Earl A, et al.
Antimicrob Agents Chemother
. 2016 Aug;
60(11):6600-6608.
PMID: 27572408
Fluoroquinolones (FQs) are effective second-line drugs for treating antibiotic-resistant tuberculosis (TB) and are being considered for use as first-line agents. Because FQs are used to treat a range of infections,...
9.
Barczak A, Gomez J, Kaufmann B, Hinson E, Cosimi L, Borowsky M, et al.
Proc Natl Acad Sci U S A
. 2012 Apr;
109(16):6217-22.
PMID: 22474362
With rising rates of drug-resistant infections, there is a need for diagnostic methods that rapidly can detect the presence of pathogens and reveal their susceptibility to antibiotics. Here we propose...
10.
Gomez J, Clatworthy A, Hung D
Crit Rev Biochem Mol Biol
. 2011 Jan;
46(1):41-66.
PMID: 21250782
Classical genetic approaches for studying bacterial pathogenesis have provided a solid foundation for our current understanding of microbial physiology and the interactions between pathogen and host. During the past decade...