James E Dunford
Overview
Explore the profile of James E Dunford including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
35
Citations
1139
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Pagnamenta A, Camps C, Giacopuzzi E, Taylor J, Hashim M, Calpena E, et al.
Genome Med
. 2023 Nov;
15(1):94.
PMID: 37946251
Background: Whole genome sequencing is increasingly being used for the diagnosis of patients with rare diseases. However, the diagnostic yields of many studies, particularly those conducted in a healthcare setting,...
2.
Dickson A, Yutuc E, Thornton C, Dunford J, Oppermann U, Wang Y, et al.
Open Biol
. 2023 May;
13(5):220313.
PMID: 37132223
Most biologically active oxysterols have a 3β-hydroxy-5-ene function in the ring system with an additional site of oxidation at C-7 or on the side-chain. In blood plasma oxysterols with a...
3.
Davis-Gilbert Z, Kramer A, Dunford J, Howell S, Senbabaoglu F, Wells C, et al.
ACS Med Chem Lett
. 2023 Apr;
14(4):432-441.
PMID: 37077385
Naphthyridine-based inhibitors were synthesized to yield a potent and cell-active inhibitor of casein kinase 2 (CK2). Compound selectively inhibits CK2α and CK2α' when profiled broadly, thereby making it an exquisitely...
4.
Sevinc K, Sevinc G, Cavga A, Philpott M, Kelekci S, Can H, et al.
Stem Cell Reports
. 2022 Nov;
17(12):2629-2642.
PMID: 36332631
Epigenetic reprogramming to pluripotency requires extensive remodeling of chromatin landscapes to silence existing cell-type-specific genes and activate pluripotency genes. ATP-dependent chromatin remodeling complexes are important regulators of chromatin structure and...
5.
Ebetino F, Sun S, Cherian P, Roshandel S, Neighbors J, Hu E, et al.
Bone
. 2021 Dec;
156:116289.
PMID: 34896359
The bisphosphonates ((HO)P(O)CRRP(O)(OH), BPs) were first shown to inhibit bone resorption in the 1960s, but it was not until 30 years later that a detailed molecular understanding of the relationship...
6.
Sandoval D, Clausen T, Nora C, Cribbs A, Denardo A, Clark A, et al.
bioRxiv
. 2021 Apr;
PMID: 33791697
We identify the prolyl-tRNA synthetase (PRS) inhibitor halofuginone , a compound in clinical trials for anti-fibrotic and anti-inflammatory applications , as a potent inhibitor of SARS-CoV-2 infection and replication. The...
7.
Foley A, Zou Y, Dunford J, Rooney J, Chandra G, Xiong H, et al.
Ann Neurol
. 2020 May;
88(2):332-347.
PMID: 32403198
Objective: A hitherto undescribed phenotype of early onset muscular dystrophy associated with sensorineural hearing loss and primary ovarian insufficiency was initially identified in 2 siblings and in subsequent patients with...
8.
Fagan V, Johansson C, Gileadi C, Monteiro O, Dunford J, Nibhani R, et al.
J Med Chem
. 2019 Sep;
62(20):9008-9025.
PMID: 31550156
Modifications of histone tails, including lysine/arginine methylation, provide the basis of a "chromatin or histone code". Proteins that contain "reader" domains can bind to these modifications and form specific effector...
9.
Ebrahimi A, Sevinc K, Sevinc G, Cribbs A, Philpott M, Uyulur F, et al.
Nat Chem Biol
. 2019 Apr;
15(5):519-528.
PMID: 30962627
Silencing of the somatic cell type-specific genes is a critical yet poorly understood step in reprogramming. To uncover pathways that maintain cell identity, we performed a reprogramming screen using inhibitors...
10.
Nikolaou N, Gathercole L, Kirkwood L, Dunford J, Hughes B, Gilligan L, et al.
J Steroid Biochem Mol Biol
. 2019 Feb;
189:218-227.
PMID: 30769091
Steroid hormones, including glucocorticoids and androgens, have potent actions to regulate many cellular processes within the liver. The steroid A-ring reductase, 5β-reductase (AKR1D1), is predominantly expressed in the liver, where...