James Bagnall
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Explore the profile of James Bagnall including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
531
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0
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Recent Articles
11.
Bagnall J, Boddington C, England H, Brignall R, Downton P, Alsoufi Z, et al.
Sci Signal
. 2018 Jul;
11(540).
PMID: 30042130
Toll-like receptor (TLR) signaling regulates macrophage activation and effector cytokine propagation in the constrained environment of a tissue. In macrophage populations, TLR4 stimulates the dose-dependent transcription of nuclear factor κB...
12.
Brignall R, Cauchy P, Bevington S, Gorman B, Pisco A, Bagnall J, et al.
J Immunol
. 2017 Sep;
199(8):2652-2667.
PMID: 28904128
TCR signaling pathways cooperate to activate the inducible transcription factors NF-κB, NFAT, and AP-1. In this study, using the calcium ionophore ionomycin and/or PMA on Jurkat T cells, we show...
13.
Phillips N, Manning C, Pettini T, Biga V, Marinopoulou E, Stanley P, et al.
Elife
. 2016 Oct;
5.
PMID: 27700985
Recent studies suggest that cells make stochastic choices with respect to differentiation or division. However, the molecular mechanism underlying such stochasticity is unknown. We previously proposed that the timing of...
14.
Daniels M, Rivers-Auty J, Schilling T, Spencer N, Watremez W, Fasolino V, et al.
Nat Commun
. 2016 Aug;
7:12504.
PMID: 27509875
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase-1 (COX-1) and COX-2 enzymes. The NLRP3 inflammasome is a multi-protein complex responsible for the processing of the proinflammatory cytokine interleukin-1β and is implicated in...
15.
Adamson A, Boddington C, Downton P, Rowe W, Bagnall J, Lam C, et al.
Nat Commun
. 2016 Jul;
7:12057.
PMID: 27381163
Cells respond dynamically to pulsatile cytokine stimulation. Here we report that single, or well-spaced pulses of TNFα (>100 min apart) give a high probability of NF-κB activation. However, fewer cells...
16.
Diamond C, Bagnall J, Spiller D, White M, Mortellaro A, Paszek P, et al.
Methods Mol Biol
. 2016 May;
1417:75-88.
PMID: 27221482
The pro-inflammatory cytokine interleukin (IL)-1β is an important mediator of the inflammatory response. In order to perform its role in the inflammatory cascade, IL-1β must be secreted from the cell,...
17.
Leedale J, Herrmann A, Bagnall J, Fercher A, Papkovsky D, See V, et al.
Math Biosci
. 2014 Sep;
258:33-43.
PMID: 25245610
HIF (hypoxia inducible factor) is an oxygen-regulated transcription factor that mediates the intracellular response to hypoxia in human cells. There is increasing evidence that cell signaling pathways encode temporal information,...
18.
Bagnall J, Leedale J, Taylor S, Spiller D, White M, Sharkey K, et al.
J Biol Chem
. 2014 Jan;
289(9):5549-64.
PMID: 24394419
Intracellular signaling involving hypoxia-inducible factor (HIF) controls the adaptive responses to hypoxia. There is a growing body of evidence demonstrating that intracellular signals encode temporal information. Thus, the dynamics of...