David G Spiller
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Explore the profile of David G Spiller including associated specialties, affiliations and a list of published articles.
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69
Citations
2007
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Recent Articles
1.
Preston R, Chrisp R, Dudek M, Morais M, Tian P, Williams E, et al.
Kidney Int
. 2024 Nov;
107(1):99-115.
PMID: 39515644
Kidney physiology shows diurnal variation, and a disrupted circadian rhythm is associated with kidney disease. However, it remains largely unknown whether glomeruli, the filtering units in the kidney, are under...
2.
Feltham L, Moran J, Goldrick M, Lord E, Spiller D, Cavet J, et al.
Front Cell Infect Microbiol
. 2024 Jul;
14:1411124.
PMID: 39045131
Dissemination of food-borne in the host relies on internalin-mediated invasion, but the underlying invasion strategies remain elusive. Here we use live-cell microscopy to follow single cell interactions between individual human...
3.
Moran J, Feltham L, Bagnall J, Goldrick M, Lord E, Nettleton C, et al.
Front Immunol
. 2023 Sep;
14:1235675.
PMID: 37675103
Pathogens have developed intricate strategies to overcome the host's innate immune responses. In this paper we use live-cell microscopy with a single bacterium resolution to follow in real time interactions...
4.
Downton P, Bagnall J, England H, Spiller D, Humphreys N, Jackson D, et al.
Front Mol Biosci
. 2023 May;
10:1187187.
PMID: 37228587
Cells respond to inflammatory stimuli such as cytokines by activation of the nuclear factor-κB (NF-κB) signalling pathway, resulting in oscillatory translocation of the transcription factor p65 between nucleus and cytoplasm...
5.
Kalliara E, Kardynska M, Bagnall J, Spiller D, Muller W, Ruckerl D, et al.
Front Immunol
. 2022 Oct;
13:947213.
PMID: 36238296
Immune cells fine tune their responses to infection and inflammatory cues. Here, using live-cell confocal microscopy and mathematical modelling, we investigate interferon-induced JAK-STAT signalling in innate immune macrophages. We demonstrate...
6.
Downton P, Sanna F, Maidstone R, Poolman T, Hayter E, Dickson S, et al.
Proc Natl Acad Sci U S A
. 2022 Apr;
119(18):e2112781119.
PMID: 35482925
Chronic inflammation underpins many human diseases. Morbidity and mortality associated with chronic inflammation are often mediated through metabolic dysfunction. Inflammatory and metabolic processes vary through circadian time, suggesting an important...
7.
Cao K, Riley J, Heilig R, Montes-Gomez A, Vringer E, Berthenet K, et al.
Dev Cell
. 2022 Apr;
57(10):1211-1225.e6.
PMID: 35447090
Mitochondrial dysfunction is interconnected with cancer. Nevertheless, how defective mitochondria promote cancer is poorly understood. We find that mitochondrial dysfunction promotes DNA damage under conditions of increased apoptotic priming. Underlying...
8.
Koch A, Bagnall J, Smyllie N, Begley N, Adamson A, Fribourgh J, et al.
Elife
. 2022 Mar;
11.
PMID: 35285799
The mammalian circadian clock exerts control of daily gene expression through cycles of DNA binding. Here, we develop a quantitative model of how a finite pool of BMAL1 protein can...
9.
McNamara A, Awais R, Momiji H, Dunham L, Featherstone K, Harper C, et al.
Endocrinology
. 2021 Jan;
162(4).
PMID: 33388754
Gene transcription occurs in short bursts interspersed with silent periods, and these kinetics can be altered by promoter structure. The effect of alternate promoter architecture on transcription bursting is not...
10.
Harper C, McNamara A, Spiller D, Charnock J, White M, Davis J
J Mol Endocrinol
. 2020 Oct;
66(1):59-69.
PMID: 33112804
Pituitary cells have been reported to show spontaneous calcium oscillations and dynamic transcription cycles. To study both processes in the same living cell in real time, we used rat pituitary...