Lipid Droplets and Cellular Lipid Flux

Overview

Journal Nat Cell Biol

Specialty Cell Biology

Date 2024 Mar 7

PMID 38454048

Authors

Alyssa J Mathiowetz

James A Olzmann

Affiliations

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Abstract

Lipid droplets are dynamic organelles that store neutral lipids, serve the metabolic needs of cells, and sequester lipids to prevent lipotoxicity and membrane damage. Here we review the current understanding of the mechanisms of lipid droplet biogenesis and turnover, the transfer of lipids and metabolites at membrane contact sites, and the role of lipid droplets in regulating fatty acid flux in lipotoxicity and cell death.

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