Melissa A Roberts
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Explore the profile of Melissa A Roberts including associated specialties, affiliations and a list of published articles.
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14
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1592
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Recent Articles
1.
Mathiowetz A, Meymand E, Deol K, Parlakgul G, Lange M, Pang S, et al.
bioRxiv
. 2024 Jun;
PMID: 38895340
Imbalances in lipid storage and secretion lead to the accumulation of hepatocyte lipid droplets (LDs) (i.e., hepatic steatosis). Our understanding of the mechanisms that govern the channeling of hepatocyte neutral...
2.
Andrews S, Kukkle P, Menon R, Geetha T, Goyal V, Kandadai R, et al.
Mov Disord
. 2023 Nov;
39(2):339-349.
PMID: 38014556
Background: Recent studies have advanced our understanding of the genetic drivers of Parkinson's disease (PD). Rare variants in more than 20 genes are considered causal for PD, and the latest...
3.
Roberts M, Deol K, Mathiowetz A, Lange M, Leto D, Stevenson J, et al.
Dev Cell
. 2023 Jul;
58(18):1782-1800.e10.
PMID: 37494933
Despite the key roles of perilipin-2 (PLIN2) in governing lipid droplet (LD) metabolism, the mechanisms that regulate PLIN2 levels remain incompletely understood. Here, we leverage a set of genome-edited human...
4.
Hendricks J, Doubravsky C, Wehri E, Li Z, Roberts M, Deol K, et al.
Cell Chem Biol
. 2023 May;
30(9):1090-1103.e7.
PMID: 37178691
Ferroptosis is a regulated form of cell death associated with the iron-dependent accumulation of phospholipid hydroperoxides. Inducing ferroptosis is a promising approach to treat therapy-resistant cancer. Ferroptosis suppressor protein 1...
5.
Mathiowetz A, Roberts M, Morgens D, Olzmann J, Li Z
STAR Protoc
. 2023 Mar;
4(2):102201.
PMID: 37000620
Phenotypic screens involving pooled CRISPR-Cas9 libraries offer a powerful, rapid yet affordable approach to evaluate gene functions on a global scale. Here, we present a protocol for performing pooled CRISPR-Cas9...
6.
Chen S, Roberts M, Chen C, Markmiller S, Wei H, Yeo G, et al.
Contact (Thousand Oaks)
. 2022 Sep;
5:25152564221125613.
PMID: 36147729
Lipid transfer proteins mediate the exchange of lipids between closely apposed membranes at organelle contact sites and play key roles in lipid metabolism, membrane homeostasis, and cellular signaling. A recently...
7.
Li Z, Ferguson L, Deol K, Roberts M, Magtanong L, Hendricks J, et al.
Nat Chem Biol
. 2022 May;
18(7):751-761.
PMID: 35637349
The selenoprotein glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid peroxides into nontoxic lipid alcohols. GPX4 has emerged as a promising therapeutic target for cancer treatment, but some cancer...
8.
Roberts M, Olzmann J
Annu Rev Cell Dev Biol
. 2020 Oct;
36:115-139.
PMID: 33021827
Lipid droplets (LDs) are endoplasmic reticulum-derived organelles that consist of a core of neutral lipids encircled by a phospholipid monolayer decorated with proteins. As hubs of cellular lipid and energy...
9.
Roberts M, Segura-Roman A, Olzmann J
Curr Biol
. 2020 Jul;
30(13):R770-R773.
PMID: 32634419
Lipid droplets (LDs) are neutral lipid storage organelles assembled at the endoplasmic reticulum (ER). A new study reveals that the high membrane curvature of ER tubules catalyzes the nucleation of...
10.
Bersuker K, Hendricks J, Li Z, Magtanong L, Ford B, Tang P, et al.
Nature
. 2019 Oct;
575(7784):688-692.
PMID: 31634900
Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation of lipids. The glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid...