Jagathpala Shetty
Overview
Explore the profile of Jagathpala Shetty including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
377
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Recent Articles
1.
Nellenbach K, Mihalko E, Nandi S, Koch D, Shetty J, Moretti L, et al.
Sci Transl Med
. 2024 Apr;
16(742):eadi4490.
PMID: 38598613
Uncontrolled bleeding after trauma represents a substantial clinical problem. The current standard of care to treat bleeding after trauma is transfusion of blood products including platelets; however, donated platelets have...
2.
Mandal A, Shetty J, Tran C, Olson W, Mandal M, Ban B, et al.
J Immunother Cancer
. 2024 Mar;
12(3).
PMID: 38485187
Background: perm crosomal LLPinding (SAS1B) protein is found in oocytes, which is necessary for sperm-oocyte interaction, and also in uterine and pancreatic cancers. Anti-SAS1B antibody-drug conjugates (ADCs) arrested growth in...
3.
Yeh C, Bingham G, Shetty J, Hu P, Barker T
Methods Mol Biol
. 2021 May;
2299:237-261.
PMID: 34028748
Aberrant deposition of the extracellular matrix (ECM) causes fibrosis and leads to ECM stiffening. This fibrotic ECM provides biological and biophysical stimulations to alter cell activity and drive progression of...
4.
Ban B, Sharma M, Shetty J
Antibodies (Basel)
. 2020 Aug;
9(3).
PMID: 32764309
Antibodies have been used for basic research, clinical diagnostics, and therapeutic applications. is one of the organisms of choice for the production of recombinant antibodies. Variable antibody genes have canonical...
5.
Coves-Datson E, Dyall J, DeWald L, King S, Dube D, Legendre M, et al.
PLoS Negl Trop Dis
. 2019 Jul;
13(7):e0007595.
PMID: 31356611
Ebolaviruses cause an often rapidly fatal syndrome known as Ebola virus disease (EVD), with average case fatality rates of ~50%. There is no licensed vaccine or treatment for EVD, underscoring...
6.
Hawkinson J, Sinville R, Mudaliar D, Shetty J, Ward T, Herr J, et al.
ChemMedChem
. 2017 Sep;
12(22):1857-1865.
PMID: 28952188
Testis-specific serine/threonine kinase 2 (TSSK2) is an important target for reversible male contraception. A high-throughput screen of ≈17 000 compounds using a mobility shift assay identified two potent series of...
7.
Zhang J, Li Z, Qie M, Zheng R, Shetty J, Wang J
Food Chem Toxicol
. 2016 May;
94:103-11.
PMID: 27237588
Fluoride and sulfur dioxide (SO2), two well-known environmental toxicants, have been implicated to have adverse effects on male reproductive health in humans and animals. The objective of this study to...
8.
Ferrer M, Xu W, Shetty J, Herr J, Oko R
Biol Reprod
. 2016 Mar;
94(4):88.
PMID: 26935599
Spermatozoa must penetrate the outer investments of the oocyte, the cumulus oophorus and the zona pellucida (ZP), in order for fertilization to occur. This may require exposure of enzymes on...
9.
Shetty J, Sinville R, Shumilin I, Minor W, Zhang J, Hawkinson J, et al.
Protein Expr Purif
. 2016 Jan;
121:88-96.
PMID: 26777341
The testis-specific serine/threonine kinase 2 (TSSK2) has been proposed as a candidate male contraceptive target. Development of a selective inhibitor for this kinase first necessitates the production of highly purified,...
10.
Suryavathi V, Panneerdoss S, Wolkowicz M, Shetty J, Sherman N, Flickinger C, et al.
Biol Reprod
. 2015 Mar;
92(5):129.
PMID: 25761597
ESP1/SPESP1 is a testis-specific, postmeiotic gene expressed in round spermatids that encodes equatorial segment protein 1, an intra-acrosomal protein found in the acrosomal matrix and on the luminal surface of...