J W Apriletti
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Explore the profile of J W Apriletti including associated specialties, affiliations and a list of published articles.
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29
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947
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Recent Articles
1.
Yoshihara H, Apriletti J, Baxter J, Scanlan T
Bioorg Med Chem Lett
. 2001 Oct;
11(21):2821-5.
PMID: 11597408
We synthesized an analogue of the thyromimetic GC-1 bearing the same hydrophobic appendage as the estrogen receptor antagonist ICI-164,384. While having reduced affinity for the thyroid hormone receptors compared to...
2.
Baxter J, Dillmann W, West B, Huber R, Furlow J, Fletterick R, et al.
J Steroid Biochem Mol Biol
. 2001 Jun;
76(1-5):31-42.
PMID: 11384861
Thyroid hormones have some actions that might be useful therapeutically, but others that are deleterious. Potential therapeutically useful actions include those to induce weight loss and lower plasma cholesterol levels....
3.
Wagner R, Huber B, Shiau A, Kelly A, Cunha Lima S, Scanlan T, et al.
Mol Endocrinol
. 2001 Feb;
15(3):398-410.
PMID: 11222741
Separate genes encode thyroid hormone receptor subtypes TRalpha (NR1A1) and TRbeta (NR1A2). Products from each of these contribute to hormone action, but the subtypes differ in tissue distribution and physiological...
4.
Ribeiro R, Feng W, Wagner R, Costa C, Pereira A, Apriletti J, et al.
J Biol Chem
. 2001 Jan;
276(18):14987-95.
PMID: 11145963
Thyroid hormone receptors (TRs) bind as homodimers or heterodimers with retinoid X receptors (RXRs) to DNA elements with diverse orientations of AGGTCA half-sites. We performed a comprehensive x-ray crystal structure-guided...
5.
Apriletti J, Ribeiro R, Wagner R, Feng W, Webb P, Kushner P, et al.
Clin Exp Pharmacol Physiol Suppl
. 1998 Nov;
25:S2-11.
PMID: 9809185
1. Thyroid hormone receptors (TR) are expressed from two separate genes (alpha and beta) and belong to the nuclear receptor superfamily, which also contains receptors for steroids, vitamins and prostaglandins....
6.
Darimont B, Wagner R, Apriletti J, Stallcup M, Kushner P, Baxter J, et al.
Genes Dev
. 1998 Nov;
12(21):3343-56.
PMID: 9808622
Combinatorial regulation of transcription implies flexible yet precise assembly of multiprotein regulatory complexes in response to signals. Biochemical and crystallographic analyses revealed that hormone binding leads to the formation of...
7.
Ribeiro R, Apriletti J, Wagner R, West B, Feng W, Huber R, et al.
Recent Prog Horm Res
. 1998 Oct;
53:351-92; discussion 392-4.
PMID: 9769715
This review summarizes the studies conducted in our laboratory on the mechanisms of thyroid hormone action over the past two decades. We have attempted to place our studies on thyroid...
8.
Ribeiro R, Apriletti J, Wagner R, Feng W, Kushner P, Nilsson S, et al.
J Steroid Biochem Mol Biol
. 1998 Aug;
65(1-6):133-41.
PMID: 9699866
We have solved several X-ray crystallographic structures of TR ligand-binding domains (LBDs), including the rat (r) TR alpha and the human (h) TR beta bound to diverse ligands. The TR-LBD...
9.
Chiellini G, Apriletti J, Yoshihara H, Baxter J, Ribeiro R, Scanlan T
Chem Biol
. 1998 Jul;
5(6):299-306.
PMID: 9653548
Background: Thyroid hormones regulate many different physiological processes in different tissues in vertebrates. Most of the actions of thyroid hormones are mediated by the thyroid hormone receptor (TR), which is...
10.
Feng W, Ribeiro R, Wagner R, Nguyen H, Apriletti J, Fletterick R, et al.
Science
. 1998 Jun;
280(5370):1747-9.
PMID: 9624051
The ligand-binding domain of nuclear receptors contains a transcriptional activation function (AF-2) that mediates hormone-dependent binding of coactivator proteins. Scanning surface mutagenesis on the human thyroid hormone receptor was performed...