J Torchia
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Explore the profile of J Torchia including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
3090
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Recent Articles
1.
Malone E, Saleh R, Yu C, Ahmed L, Pugh T, Torchia J, et al.
Curr Oncol
. 2019 Nov;
26(5):e618-e623.
PMID: 31708655
Cancer is a genetic disease resulting from germline or somatic genetic aberrations. Rapid progress in the field of genomics in recent years is allowing for increased characterization and understanding of...
2.
Chitilian J, Thillainadesan G, Manias J, Chang W, Walker E, Isovic M, et al.
Stem Cells
. 2013 Oct;
32(1):204-15.
PMID: 24115386
p/CIP, also known as steroid receptor coactivator 3 (SRC-3)/Nuclear Receptor Coactivator 3 (NCoA3), is a transcriptional coactivator that binds liganded nuclear hormone receptors, as well as other transcription factors, and...
3.
Coughlan N, Thillainadesan G, Andrews J, Isovic M, Torchia J
Biochim Biophys Acta
. 2013 Feb;
1833(6):1463-75.
PMID: 23434684
The steroid receptor coactivator p/CIP, also known as SRC-3, is an oncogene commonly amplified in breast and ovarian cancers. p/CIP is known to associate with coactivator arginine methyltransferase 1 (CARM1)...
4.
Fonseca G, Thillainadesan G, Yousef A, Ablack J, Mossman K, Torchia J, et al.
Cell Host Microbe
. 2012 Jun;
11(6):597-606.
PMID: 22704620
Overcoming the cellular type I interferon (IFN) host defense response is critical for a virus to ensure successful infection. Investigating the effects of human adenovirus (HAdV) infection on global cellular...
5.
Cowger J, Zhao Q, Isovic M, Torchia J
Oncogene
. 2006 Nov;
26(23):3378-86.
PMID: 17130829
Zinc-finger protein 217 (ZNF217) is a Kruppel-like zinc-finger protein located at 20q13.2, within a region of recurrent maximal amplification. Here, we demonstrate that ZNF217 is a transcriptional repressor protein and...
6.
Bhattacharjee R, Underhill C, Torchia J
Methods Mol Biol
. 2001 Sep;
176:249-60.
PMID: 11554326
No abstract available.
7.
Underhill C, Qutob M, Yee S, Torchia J
J Biol Chem
. 2000 Oct;
275(51):40463-70.
PMID: 11013263
Transcriptional silencing by many transcription factors is mediated by the nuclear receptor corepressor (N-CoR). The mechanism by which N-CoR represses basal transcription involves the direct or indirect recruitment of histone...
8.
McInerney E, Rose D, FLYNN S, Westin S, Mullen T, Krones A, et al.
Genes Dev
. 1998 Nov;
12(21):3357-68.
PMID: 9808623
Ligand-dependent activation of gene transcription by nuclear receptors is dependent on the recruitment of coactivators, including a family of related NCoA/SRC factors, via a region containing three helical domains sharing...
9.
Torchia J, Glass C, Rosenfeld M
Curr Opin Cell Biol
. 1998 Jun;
10(3):373-83.
PMID: 9640539
The nuclear hormone receptors are DNA binding transcription factors that are regulated by binding of ligands, switching them from an inactive or repressive state to gene-activating functions. Recent evidence supports...
10.
Lavinsky R, Jepsen K, Heinzel T, Torchia J, Mullen T, Schiff R, et al.
Proc Natl Acad Sci U S A
. 1998 Apr;
95(6):2920-5.
PMID: 9501191
Several lines of evidence indicate that the nuclear receptor corepressor (N-CoR) complex imposes ligand dependence on transcriptional activation by the retinoic acid receptor and mediates the inhibitory effects of estrogen...