J Silvio Gutkind
Overview
Explore the profile of J Silvio Gutkind including associated specialties, affiliations and a list of published articles.
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381
Citations
17082
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Recent Articles
1.
He J, Chai X, Zhang Q, Wang Y, Wang Y, Yang X, et al.
Nat Immunol
. 2025 Mar;
PMID: 40065162
No abstract available.
2.
Lubrano S, Cervantes-Villagrana R, Faraji F, Ramirez S, Sato K, Adame-Garcia S, et al.
Cancer Cell
. 2025 Feb;
43(3):428-445.e6.
PMID: 40020669
Widespread BRAF mutations result in persistent RAS-RAF-MEK-ERK (MAPK) signaling in melanoma. BRAF (BRAFi) and MEK (MEKi) inhibitors are approved for BRAF V600E melanomas, including those progressing on immunotherapy; however, rapid...
3.
Wang C, Yu K, Chen T, Tsai M, Kang C, Chien C, et al.
Oral Oncol
. 2025 Feb;
162:107210.
PMID: 39947008
Background: To characterize multistate oral carcinogenesis, we conducted a cohort study of patients with oral precancer and a parallel case-control study of oral cancers and controls in Taiwan. Methods: During...
4.
He J, Chai X, Zhang Q, Wang Y, Wang Y, Yang X, et al.
Nat Immunol
. 2025 Feb;
26(3):391-403.
PMID: 39905201
Most patients with colorectal cancer do not achieve durable clinical benefits from immunotherapy, underscoring the existence of alternative immunosuppressive mechanisms. Here we found that activation of the lactate receptor HCAR1...
5.
Ferry A, Mempel K, Monell A, Reina-Campos M, Scharping N, Heeg M, et al.
J Exp Med
. 2025 Jan;
222(2.
PMID: 39841133
Tissue-resident memory T cells (TRM) provide frontline protection against pathogens and emerging malignancies. Tumor-infiltrating lymphocytes (TIL) with TRM features are associated with improved clinical outcomes. However, the cellular interactions that...
6.
Sato K, Faraji F, Cervantes-Villagrana R, Wu X, Koshizuka K, Ishikawa T, et al.
Cancer Lett
. 2025 Jan;
612:217467.
PMID: 39826667
Genetic alterations in Hippo pathway and the consequent activation of YAP/TAZ-TEAD are frequently observed in HPV-negative head and neck squamous cell carcinoma (HNSCC) patients. These include loss-of-function mutation and/or copy...
7.
Faraji F, Ramirez S, Clubb L, Sato K, Burghi V, Hoang T, et al.
Nat Commun
. 2025 Jan;
16(1):498.
PMID: 39779672
Tumor initiation represents the first step in tumorigenesis during which normal progenitor cells undergo cell fate transition to cancer. Capturing this process as it occurs in vivo, however, remains elusive....
8.
Mortaja M, Cheng M, Ali A, Lesperance J, Hingorani D, Allevato M, et al.
Molecules
. 2024 Dec;
29(23).
PMID: 39683778
Chemotherapies remain standard therapy for cancers but have limited efficacy and cause significant side effects, highlighting the need for targeted approaches. In the progression of cancer, tumors increase matrix metalloproteinase...
9.
Novoplansky O, Jagadeeshan S, Prasad M, Yegodayev K, Marripati D, Shareb R, et al.
J Exp Clin Cancer Res
. 2024 Nov;
43(1):308.
PMID: 39567998
Background: Basket clinical trials targeting the KRAS-mutation in solid tumors have shown initial promise, including in orphan KRAS head and neck cancer (HNC). However, development of resistance to KRAS-mutant-specific inhibitors...
10.
Sajib M, Zahra F, Lamprou M, Akwii R, Park J, Osorio M, et al.
bioRxiv
. 2024 Oct;
PMID: 39372784
The endothelial barrier plays an active role in transendothelial tumor cell migration during metastasis, however, the endothelial regulatory elements of this step remain obscure. Here we show that endothelial RhoA...