J P NORTHROP
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Explore the profile of J P NORTHROP including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
2015
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Recent Articles
1.
NORTHROP J, Nguyen D, Piplani S, Olivan S, Kwan S, Go N, et al.
Mol Endocrinol
. 2000 May;
14(5):605-22.
PMID: 10809226
Steroid and thyroid hormone receptors are members of the superfamily of nuclear receptors (NR) that participate in developmental and homeostatic mechanisms by changes in the transcription of specific genes. These...
2.
Mattheakis L, Olivan S, Dias J, NORTHROP J
Chem Biol
. 1999 Nov;
6(11):835-44.
PMID: 10574783
Background: Cell-based reporter assays, which rely on a reporter gene under the control of a regulated promoter, are widely used to screen chemical libraries for novel receptor ligands. Here, we...
3.
Hart C, Martin J, Reed M, Keval A, Pustelnik M, NORTHROP J, et al.
Cell Signal
. 1999 Jul;
11(6):453-64.
PMID: 10400318
We cloned and expressed the SH2 domain of human GRB2 as glutathione S-transferase and maltose binding protein fusion proteins. We screened three phagemid-based fd pVIII-protein phage display libraries against SH2...
4.
Xing H, NORTHROP J, Grove J, Kilpatrick K, Su J, Ringold G
Endocrinology
. 1997 Jul;
138(7):2776-83.
PMID: 9202217
Tumor necrosis factor alpha (TNF alpha) is a polypeptide hormone with pleiotropic effects on cellular proliferation and differentiation. To investigate how TNF alpha inhibits and reverses adipocyte differentiation, we studied...
5.
Timmerman L, Clipstone N, Ho S, NORTHROP J, Crabtree G
Nature
. 1996 Oct;
383(6603):837-40.
PMID: 8893011
Cells need to distinguish between transient Ca2+ signals that induce events such as muscle contraction, secretion, adhesion and synaptic transmission, and sustained Ca2+ signals that are involved in cell proliferation...
6.
NORTHROP J, Pustelnik M, Lu A, Grove J
Mol Cell Biol
. 1996 May;
16(5):2255-63.
PMID: 8628292
Activation of the T-cell antigen receptor initiates a complex signaling cascade leading to changes in cytokine gene transcription. Several proteins containing Src homology 2 (SH2) domains, capable of interacting with...
7.
NORTHROP J, Ho S, Chen L, Thomas D, Timmerman L, Nolan G, et al.
Nature
. 1994 Jun;
369(6480):497-502.
PMID: 8202141
The NF-AT transcription complex is required for the expression of a group of proteins that collectively coordinate the immune response. Here we purify two proteins encoded by separate genes that...
8.
NORTHROP J, Ullman K, Crabtree G
J Biol Chem
. 1993 Feb;
268(4):2917-23.
PMID: 8428966
The lymphoid-specific transcription complex, NF-AT, is involved in early gene activation in T cells and is assembled from a pre-existing, T cell restricted cytoplasmic factor and an inducible ubiquitous nuclear...
9.
Ullman K, NORTHROP J, Admon A, Crabtree G
Genes Dev
. 1993 Feb;
7(2):188-96.
PMID: 8436291
The octamer-binding transcription factor Oct-1 is involved in a wide variety of cellular processes but appears to lack a strong transcriptional activation domain, suggesting that it functions in the context...
10.
NORTHROP J, Crabtree G, Mattila P
J Exp Med
. 1992 May;
175(5):1235-45.
PMID: 1569395
Glucocorticoid-dependent transcriptional enhancement is known to occur through the interaction of the glucocorticoid receptor (GR) with specific DNA response elements. In contrast, negative regulation of gene expression by this class...