J Michael Shipley
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Explore the profile of J Michael Shipley including associated specialties, affiliations and a list of published articles.
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26
Citations
1482
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Recent Articles
1.
Combs M, Knutsen R, Broekelmann T, Toennies H, Brett T, Miller C, et al.
J Biol Chem
. 2013 Aug;
288(40):28869-80.
PMID: 23963447
Microfibril-associated glycoprotein (MAGP) 1 and 2 are evolutionarily related but structurally divergent proteins that are components of microfibrils of the extracellular matrix. Using mice with a targeted inactivation of Mfap5,...
2.
Hu Q, Shifren A, Sens C, Choi J, Szabo Z, Starcher B, et al.
Matrix Biol
. 2010 Jul;
29(7):621-8.
PMID: 20600892
Heterozygous elastin gene mutations cause autosomal dominant cutis laxa associated with emphysema and aortic aneurysms. To investigate the molecular mechanisms leading to cutis laxa in vivo, we generated transgenic mice...
3.
Kyriakides T, Wulsin D, Skokos E, Fleckman P, Pirrone A, Shipley J, et al.
Matrix Biol
. 2009 Apr;
28(2):65-73.
PMID: 19379668
Matrix metalloproteinase- (MMP-9) is involved in processes that occur during cutaneous wound healing such as inflammation, matrix remodeling, and epithelialization, To investigate its role in healing, full thickness skin wounds...
4.
MacLauchlan S, Skokos E, Meznarich N, Zhu D, Raoof S, Shipley J, et al.
J Leukoc Biol
. 2009 Jan;
85(4):617-26.
PMID: 19141565
Macrophages undergo fusion to form multinucleated giant cells in several pathologic conditions, including the foreign body response (FBR). We detected high levels of matrix metalloproteinase (MMP)-9 during macrophage fusion in...
5.
Mydel P, Shipley J, Adair-Kirk T, Kelley D, Broekelmann T, Mecham R, et al.
J Biol Chem
. 2008 Jan;
283(15):9513-22.
PMID: 18178964
Proteolytic processing of laminin-332 by matrix metalloproteinase (MMP)-2 and MMP-14 has been shown to yield fragments that are promigratory for epithelial cells. During acute and chronic inflammation, proteases are elaborated...
6.
Zhang Y, Huang G, Shornick L, Roswit W, Shipley J, Brody S, et al.
Am J Respir Cell Mol Biol
. 2007 Jan;
36(5):515-9.
PMID: 17255554
Ciliated airway epithelial cells are critical for mucosal barrier function, including host defense against pathogens. This cell population is often the primary target and thereby the first line of defense...
7.
Polgar N, Fogelgren B, Shipley J, Csiszar K
J Biol Chem
. 2006 Nov;
282(5):3262-72.
PMID: 17130123
Lysyl oxidase (LOX), an extracellular amine oxidase, catalyzes the cross-linking of collagen and elastin. LOX has been also shown to play an essential role in promoting the invasive and metastatic...
8.
Zhang L, Ikegami M, Korfhagen T, McCormack F, Yoshida M, Senior R, et al.
Am J Physiol Lung Cell Mol Physiol
. 2006 Feb;
291(2):L181-90.
PMID: 16500946
Surfactant proteins (SP)-A and -D are members of the collectin family of host defense proteins that share four distinct structural domains: NH(2)-terminal oligomerization, collagenous, neck, and carbohydrate recognition (CRD). To...
9.
Miyamoto A, Lau R, Hein P, Shipley J, Weinmaster G
J Biol Chem
. 2006 Feb;
281(15):10089-97.
PMID: 16492672
Unlike most receptors, Notch serves as both the receiver and direct transducer of signaling events. Activation can be mediated by one of five membrane-bound ligands of either the Delta-like (-1,...
10.
Ito S, Bartolak-Suki E, Shipley J, Parameswaran H, Majumdar A, Suki B
Am J Respir Cell Mol Biol
. 2006 Jan;
34(6):688-94.
PMID: 16439805
The nature of the development of emphysema in the tight skin (Tsk) and the pallid (Pa) mice are not well understood. We assessed the mechanical and nonlinear properties of the...