Raphael Lemaire
Overview
Explore the profile of Raphael Lemaire including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
753
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0
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Recent Articles
1.
Pineiro-Hermida S, Martinez P, Bosso G, Maria Flores J, Saraswati S, Connor J, et al.
Nat Commun
. 2022 Oct;
13(1):5656.
PMID: 36202783
TRF1 is an essential component of the telomeric protective complex or shelterin. We previously showed that dysfunctional telomeres in alveolar type II (ATII) cells lead to interstitial lung fibrosis. Here,...
2.
Cottage C, Peterson N, Kearley J, Berlin A, Xiong X, Huntley A, et al.
Commun Biol
. 2019 Aug;
2:307.
PMID: 31428695
Senescence is a mechanism associated with aging that alters tissue regeneration by depleting the stem cell pool. Chronic obstructive pulmonary disease (COPD) displays hallmarks of senescence, including a diminished stem...
3.
Sargent J, Li Z, Aliprantis A, Greenblatt M, Lemaire R, Wu M, et al.
Arthritis Rheumatol
. 2016 Mar;
68(8):2003-15.
PMID: 26945694
Objective: Understanding the pathogenesis of systemic sclerosis (SSc) is confounded by considerable disease heterogeneity. Animal models of SSc that recapitulate distinct subsets of disease at the molecular level have not...
4.
Lemaire R, Burwell T, Sun H, Delaney T, Bakken J, Cheng L, et al.
Arthritis Rheumatol
. 2015 Sep;
68(2):473-83.
PMID: 26414805
Objective: Systemic sclerosis (SSc) is a fibrotic disease characterized by an obliterative vasculopathy with thrombosis and impairment of the coagulation-fibrinolysis balance. Plasminogen activator inhibitor 1 (PAI-1) is the major inhibitor...
5.
Pendergrass S, Lemaire R, Francis I, Mahoney J, Lafyatis R, Whitfield M
J Invest Dermatol
. 2012 Feb;
132(5):1363-73.
PMID: 22318389
Skin biopsy gene expression was analyzed by DNA microarray from 13 diffuse cutaneous systemic sclerosis (dSSc) patients enrolled in an open-label study of rituximab, 9 dSSc patients not treated with...
6.
Pendergrass S, Hayes E, Farina G, Lemaire R, Farber H, Whitfield M, et al.
PLoS One
. 2010 Sep;
5(8):e12106.
PMID: 20808962
Background: Pulmonary arterial hypertension (PAH) is a common complication for individuals with limited systemic sclerosis (lSSc). The identification and characterization of biomarkers for lSSc-PAH should lead to less invasive screening,...
7.
Lemaire R, Farina G, Bayle J, DiMarzio M, Pendergrass S, Milano A, et al.
J Invest Dermatol
. 2010 Feb;
130(6):1514-23.
PMID: 20182440
Abnormal fibrillinogenesis is associated with connective tissue disorders (CTDs), including Marfan syndrome (MFS), systemic sclerosis (SSc) and Tight-skin (Tsk) mice. We have previously shown that TGF-beta and Wnt stimulate fibrillin-1...
8.
Bayle J, Fitch J, Jacobsen K, Kumar R, Lafyatis R, Lemaire R
J Invest Dermatol
. 2007 Oct;
128(4):871-81.
PMID: 17943183
Systemic sclerosis (SSc) is a complex human disorder characterized by progressive skin fibrosis. To better understand the molecular basis of dermal fibrosis in SSc, we analyzed microarray gene expression in...
9.
York M, Nagai T, Mangini A, Lemaire R, van Seventer J, Lafyatis R
Arthritis Rheum
. 2007 Mar;
56(3):1010-20.
PMID: 17328080
Objective: Microarray analyses of peripheral blood leukocytes have shown that patients with systemic lupus erythematosus express increased levels of type I interferon (IFN)-regulated genes. In this study we examined gene...
10.
Aliprantis A, Wang J, Fathman J, Lemaire R, Dorfman D, Lafyatis R, et al.
Proc Natl Acad Sci U S A
. 2007 Feb;
104(8):2827-30.
PMID: 17307869
Tissue remodeling with fibrosis is a predominant pathophysiological mechanism of many human diseases. Systemic sclerosis is a rare, often lethal, disorder of unknown etiology manifested by dermal fibrosis (scleroderma) and...