J Hesselgesser
Overview
Explore the profile of J Hesselgesser including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
1554
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Recent Articles
1.
Trebst C, Sorensen T, Kivisakk P, Cathcart M, Hesselgesser J, Horuk R, et al.
Ernst Schering Res Found Workshop
. 2002 Jun;
(39):193-211.
PMID: 12066413
No abstract available.
2.
Trebst C, Sorensen T, Kivisakk P, Cathcart M, Hesselgesser J, Horuk R, et al.
Am J Pathol
. 2001 Nov;
159(5):1701-10.
PMID: 11696431
Mononuclear phagocytes (monocytes, macrophages, and microglia) are considered central to multiple sclerosis (MS) pathogenesis. Molecular cues that mediate mononuclear phagocyte accumulation and activation in the central nervous system (CNS) of...
3.
Goldberg S, van der Meer P, Hesselgesser J, Jaffer S, Kolson D, Albright A, et al.
Neuropathol Appl Neurobiol
. 2001 Jul;
27(2):127-38.
PMID: 11437993
The CXCR3 chemokine receptor, expressed on activated T lymphocytes, is seen within the central nervous system (CNS) in inflammatory conditions where a T-cell response is prominent. However, the distribution of...
4.
Horuk R, Shurey S, Ng H, May K, Bauman J, Islam I, et al.
Immunol Lett
. 2001 Apr;
76(3):193-201.
PMID: 11306147
The classic signs of acute cellular rejection during organ transplantation include the infiltration of mononuclear cells into the interstitium. This recruitment of leukocytes into the transplanted tissue is promoted by...
5.
Horuk R, Clayberger C, Krensky A, Wang Z, Grone H, Weber C, et al.
J Biol Chem
. 2000 Oct;
276(6):4199-204.
PMID: 11054419
Chemokines like RANTES appear to play a role in organ transplant rejection. Because RANTES is a potent agonist for the chemokine receptor CCR1, we examined whether the CCR1 receptor antagonist...
6.
Wu D, Woodman S, Weiss J, McManus C, DAversa T, Hesselgesser J, et al.
J Neurovirol
. 2000 Jun;
6 Suppl 1:S82-5.
PMID: 10871769
HIV-1 encephalitis occurs in up to one-third of HIV-1-infected individuals. The mechanisms through which this pathology develops are thought to involve viral passage across the blood-brain barrier (BBB), as well...
7.
Choe W, Albright A, Sulcove J, Jaffer S, Hesselgesser J, Lavi E, et al.
J Neurovirol
. 2000 Jun;
6 Suppl 1:S61-9.
PMID: 10871767
APJ is a recently described seven-transmembrane (7TM) receptor that is abundantly expressed in the central nervous system (CNS). This suggests an important role for APJ in neural development and/or function,...
8.
Coughlan C, McManus C, Sharron M, Gao Z, Murphy D, Jaffer S, et al.
Neuroscience
. 2000 Jun;
97(3):591-600.
PMID: 10828541
Functional chemokine receptors and chemokines are expressed by glial cells within the CNS, though relatively little is known about the patterns of neuronal chemokine receptor expression and function. We developed...
9.
McManus C, Weidenheim K, Woodman S, Nunez J, Hesselgesser J, Nath A, et al.
Am J Pathol
. 2000 Apr;
156(4):1441-53.
PMID: 10751368
Human immunodeficiency virus (HIV) encephalitis is a prominent pathology seen in children infected with HIV. Immunohistochemical analyses of pediatric brain tissue showed distinct differences in expression of C-C chemokines and...
10.
Liang M, Mallari C, Rosser M, Ng H, May K, Monahan S, et al.
J Biol Chem
. 2000 Apr;
275(25):19000-8.
PMID: 10748002
The CC chemokine receptor-1 (CCR1) is a prime therapeutic target for treating autoimmune diseases. Through high capacity screening followed by chemical optimization, we identified a novel non-peptide CCR1 antagonist, R-N-[5-chloro-2-[2-[4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl...