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R Horuk

Explore the profile of R Horuk including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 99
Citations 4028
Followers 0
Related Specialties
Biochemistry
Allergy & Immunology
General Medicine
Top 10 Co-Authors
J Hesselgesser
S C Peiper
R C Newton
S Matthaei
H P Ng
H D Perez
J M Olefsky
M Liang
T J Hadley
J G Bauman
Published In
J Biol Chem
Methods Enzymol
J Immunol
Biochim Biophys Acta
Biochem J
Affiliations
Soon will be listed here.
Recent Articles
1.
Beneficial effects of CCR1 blockade on the progression of chronic renal allograft damage
Bedke J, Kiss E, Schaefer L, Behnes C, Bonrouhi M, Gretz N, et al.
Am J Transplant . 2007 Jan; 7(3):527-37. PMID: 17229070
The biology of chemokines and their receptors have been linked to the development of chronic allograft damage. Effects of CCR1 antagonist BX 471 were studied in a Fischer to Lewis...
2.
The discovery and therapeutic applications of CCR1 chemokine receptor antagonists
Horuk R, Ng H
IDrugs . 2005 Sep; 2(5):418-25. PMID: 16155844
Chemokines belong to a large family of chemoattractant molecules involved in the directed migration of immune cells. They achieve their cellular effects by direct interaction with cell surface receptors. One...
3.
Preliminary observations on CC chemokine receptor expression by mononuclear phagocytes in multiple sclerosis lesions: effect of lesion heterogeneity
Mahad D, Trebst C, Staugaitis S, Kivisakk P, Tucky B, Wei T, et al.
Ernst Schering Res Found Workshop . 2004 Jan; (45):59-68. PMID: 14699794
No abstract available.
4.
Chemokine receptor antagonists from discovery to the clinic
Horuk R
Ernst Schering Res Found Workshop . 2003 Oct; (44):169-90. PMID: 14579780
No abstract available.
5.
Chemokine receptors on mononuclear phagocytes in the central nervous system of patients with multiple sclerosis
Trebst C, Sorensen T, Kivisakk P, Cathcart M, Hesselgesser J, Horuk R, et al.
Ernst Schering Res Found Workshop . 2002 Jun; (39):193-211. PMID: 12066413
No abstract available.
6.
CCR1+/CCR5+ mononuclear phagocytes accumulate in the central nervous system of patients with multiple sclerosis
Trebst C, Sorensen T, Kivisakk P, Cathcart M, Hesselgesser J, Horuk R, et al.
Am J Pathol . 2001 Nov; 159(5):1701-10. PMID: 11696431
Mononuclear phagocytes (monocytes, macrophages, and microglia) are considered central to multiple sclerosis (MS) pathogenesis. Molecular cues that mediate mononuclear phagocyte accumulation and activation in the central nervous system (CNS) of...
7.
Chemokine-Induced secretion of gelatinase B in primary human monocytes
Klier C, Nelson E, Cohen C, Horuk R, Schlondorff D, Nelson P
Biol Chem . 2001 Nov; 382(9):1405-10. PMID: 11688724
Chemokines help control normal leukocyte trafficking as well as their infiltration into tissues during acute and chronic inflammation. Matrix metalloproteinases (MMPs) help support the extravasation and infiltration of leukocytes through...
8.
Chemokine receptors
Horuk R
Cytokine Growth Factor Rev . 2001 Sep; 12(4):313-35. PMID: 11544102
Although chemokines were originally defined as host defense proteins it is now clear that their repertoire of functions extend well beyond this role. For example chemokines such as MGSA have...
9.
CCR1-specific non-peptide antagonist: efficacy in a rabbit allograft rejection model
Horuk R, Shurey S, Ng H, May K, Bauman J, Islam I, et al.
Immunol Lett . 2001 Apr; 76(3):193-201. PMID: 11306147
The classic signs of acute cellular rejection during organ transplantation include the infiltration of mononuclear cells into the interstitium. This recruitment of leukocytes into the transplanted tissue is promoted by...
10.
Specialized roles of the chemokine receptors CCR1 and CCR5 in the recruitment of monocytes and T(H)1-like/CD45RO(+) T cells
Weber C, Weber K, Klier C, Gu S, Wank R, Horuk R, et al.
Blood . 2001 Feb; 97(4):1144-6. PMID: 11159551
Chemokines and their receptors control the emigration of leukocytes during inflammation. The role of the RANTES (regulated on activation normal T-cell expressed and secreted) receptors CCR1 and CCR5 in the...