J H Poupaert
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Explore the profile of J H Poupaert including associated specialties, affiliations and a list of published articles.
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Citations
134
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Recent Articles
1.
Kapanda C, Poupaert J, Lambert D
Curr Med Chem
. 2013 Feb;
20(14):1824-46.
PMID: 23410152
Endocannabinoid hydrolases are nowadays increasingly considered as potential therapeutic targets for treating several pathological states. So far, numerous classes of endocannabinoid hydrolase inhibitors have been described. We herein review the...
2.
Tytgat I, Colacino E, Tulkens P, Poupaert J, Prevost M, Van Bambeke F
Curr Med Chem
. 2009 Jul;
16(20):2566-80.
PMID: 19601798
DD-ligases catalyze the synthesis of the D-Ala-D-Ala and D-Ala-D-Ser dipeptides or the D Ala-D-Lac depsipeptide in an early step of peptidoglycan synthesis. Their function is essential for bacterial growth and...
3.
Yous S, Poupaert J, Chavatte P, Espiard J, Caignard D, Lesieur D
Drug Des Discov
. 2002 Jan;
17(4):331-6.
PMID: 11765136
A series of novel 6-substituted-2(3H)-benzothiazolones were synthesized and studied as analgesic agents. Among these compounds, two of them were found to exhibit potent analgesic activity in several in vivo tests...
4.
Diouf O, Depreux P, Chavatte P, Poupaert J
Eur J Med Chem
. 2000 Aug;
35(7-8):699-706.
PMID: 10960185
The indole derivative GR 113808 is currently used as the reference ligand for labelling the 5-HT(4) serotoninergic receptors. Previous works in our laboratories established the bioisosteric equivalency of the indole...
5.
Kanyonyo M, Govaerts S, Hermans E, Poupaert J, Lambert D
Bioorg Med Chem Lett
. 1999 Aug;
9(15):2233-6.
PMID: 10465552
Twenty-four 3-alkyl-(5,5'-diphenyl)imidazolidinediones were synthesized and evaluated as new cannabinoid receptor ligands. Three compounds exhibited a Ki value around 100 nM against [3H]-SR 141716A binding obtained from human CB1 transfected CHO...
6.
Van Derpoorten K, Ucar H, Andrei G, Snoeck R, Balzarini J, De Clercq E, et al.
Antivir Chem Chemother
. 1999 May;
10(2):87-97.
PMID: 10335403
The synthesis and antiviral activity of an original series of 6-benzoyl-benzoxazolin-2-one and 6-benzoyl-benzothiazolin-2-one derivatives are described. Several compounds were found to have a selective inhibitory activity against human cytomegalovirus (HCMV)...
7.
Bourhim M, Poupaert J, Stables J, Vallee L, Vamecq J
Arzneimittelforschung
. 1999 Mar;
49(2):81-7.
PMID: 10083974
Design, anticonvulsant properties in maximal electroshock-induced seizures [MES] and seizures induced by subcutaneous administration of pentetrazole (scPtz), and neurotoxicity of retrobenzamides (N-(nitrophenyl)benzamides and N-(aminophenyl) benzamides are reported. These data are...
8.
Vamecq J, Van Derpoorten K, Poupaert J, Balzarini J, De Clercq E, Stables J
Life Sci
. 1998 Nov;
63(19):PL267-74.
PMID: 9806229
This work is aimed at further exploring the concept that phenytoin-related compounds might present with an anti-HIV potential. We screened for anti-HIV activity, selected compounds whose structural design rests on...
9.
Gozzo F, Poupaert J
J Pharm Belg
. 1998 Oct;
53(4):278-86.
PMID: 9766095
This review article provides basic information concerning the xenoestrogens (i.e. the sexual hormone mimetic or disruptive compounds) in a perspective willingly selective of the recent literature. In the second part,...
10.
Vamecq J, Lambert D, Poupaert J, Masereel B, Stables J
J Med Chem
. 1998 Aug;
41(18):3307-13.
PMID: 9719582
Fifteen compounds related to ameltolide (LY 201116) were studied for (i) anticonvulsant potential in the maximal electroshock-induced seizures (MES) and the subcutaneous pentylenetetrazol (sc Ptz) tests in mice and rats...