J H Poupaert
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Explore the profile of J H Poupaert including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Taverne T, Diouf O, Depreux P, Poupaert J, Lesieur D, Guardiola-Lemaitre B, et al.
J Med Chem
. 1998 Jun;
41(12):2010-8.
PMID: 9622542
Since it was known that 5HT properties (5HT1A agonism or 5HT2A antagonism) combined with D2 antagonism may lead to atypical antipsychotic drugs, a series of 19 benzothiazolin-2-one and benzoxazin-3-one derivatives...
12.
Ucar H, Van Derpoorten K, Cacciaguerra S, Spampinato S, Stables J, Depovere P, et al.
J Med Chem
. 1998 Apr;
41(7):1138-45.
PMID: 9544213
A series of 2(3H)-benzoxazolone and 2(3H)-benzothiazolone derivatives were synthesized and evaluated for anticonvulsant activity. The compounds were assayed, intraperitoneally in mice and per os in rats, against seizures induced by...
13.
Kanyonyo M, Poupaert J, Lambert D
Pharmacol Toxicol
. 1998 Apr;
82(1):47-50.
PMID: 9527647
An original ameltolide analogue 4-amino-(2-methyl-4-aminophenyl)benzamide, in which a second amino group has been introduced, was synthesized and evaluated for anticonvulsant activity. After intraperitoneal administration to mice, 4-amino-(2-methyl-4-aminophenyl)benzamide was found active...
14.
Bourhim M, Kanyonyo M, Lambert D, Poupaert J, Stables J, Vamecq J
J Pharm Belg
. 1998 Feb;
52(5):181-9.
PMID: 9432526
Retrobenzamides [N-(nitrophenyl) benzamides and N-(aminophenyl)benzamides] were developed in the perpective of a design for phenytoinergic agents. Anticonvulsant and neurotoxic properties of these compounds were evaluated in mice and rats in...
15.
Geurts M, Poupaert J, Scriba G, Lambert D
J Med Chem
. 1998 Jan;
41(1):24-30.
PMID: 9438018
Glycine is a small neutral amino acid exhibiting weak anticonvulsant activities in vivo. Recently, studies have demonstrated that N-(benzyloxycarbonyl)glycine (1) antagonized seizures superior to glycine in addition to activity in...
16.
Ucar H, Cacciaguerra S, Spampinato S, Van Derpoorten K, Isa M, Kanyonyo M, et al.
Eur J Pharmacol
. 1997 Nov;
335(2-3):267-73.
PMID: 9369382
A series of original 2(3H)-benzoxazolone and 2(3H)-benzothiazolone derivatives were evaluated for their affinity at sigma1 and sigma2 receptor subtypes in competition binding experiments, using [3H](+)-pentazocine or [3H]1,3-di-o-tolyl-guanidine (DTG) in the...
17.
Masereel B, Lambert D, Dogne J, Poupaert J, DELARGE J
Epilepsia
. 1997 Mar;
38(3):334-7.
PMID: 9070596
The N-[(4-cycloheptylaminopyrid-3-yl)sulfonyl]-N'-cycloheptyl urea, a neuroprotective agent, and 10 chemically related sulfonyl(thio)ureas were evaluated in the maximal electroshock seizure test in mice. This sulfonylurea, BM 27, and two structurally related sulfonylthioureas,...
18.
Van Derpoorten K, Balzarini J, De Clercq E, Poupaert J
Biomed Pharmacother
. 1997 Jan;
51(10):464-8.
PMID: 9863507
The discovery of new leads acting via novel modes of action in the treatment of the human immunodeficiency virus (HIV), the causative agent of AIDS, remains a challenge. Along this...
19.
Diouf O, Bourhim M, Lambert D, Poupaert J, Stables J, Vamecq J
Biomed Pharmacother
. 1997 Jan;
51(3):131-6.
PMID: 9181049
A well documented study on the anticonvulsant properties of 4-amino-N-(2-ethylphenyl)benzamide (4-AEPB) is here provided. Initial screening in mice dosed intraperitoneally and rats dosed orally indicated that 4-AEPB is active against...
20.
Isa M, Cumps J, Poupaert J, Atassi G
J Pharm Belg
. 1996 Jul;
51(4):192-4.
PMID: 8965249
No abstract available.