J Fraser Wright
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Explore the profile of J Fraser Wright including associated specialties, affiliations and a list of published articles.
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70
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Recent Articles
31.
32.
McDonald C, Benson J, Cornetta K, Diggins M, Johnston J, Sepelak S, et al.
Hum Gene Ther Clin Dev
. 2013 May;
24(1):5-10.
PMID: 23692378
Abstract Translational research is a lengthy, complex, and necessary endeavor in order to bring basic science discoveries to clinical fruition. The NIH offers several programs to support translational research including...
33.
Grupp S, Kalos M, Barrett D, Aplenc R, Porter D, Rheingold S, et al.
N Engl J Med
. 2013 Mar;
368(16):1509-1518.
PMID: 23527958
Chimeric antigen receptor-modified T cells with specificity for CD19 have shown promise in the treatment of chronic lymphocytic leukemia (CLL). It remains to be established whether chimeric antigen receptor T...
34.
Jin S, Xiao J, Bao J, Zhou S, Wright J, Zheng X
Blood
. 2013 Mar;
121(19):3825-9, S1-3.
PMID: 23515928
Severe deficiency of plasma ADAMTS13 activity causes thrombotic thrombocytopenic purpura (TTP), a life-threatening syndrome for which plasma is the only effective therapy currently available. As much as 5% of TTP...
35.
Testa F, Maguire A, Rossi S, Pierce E, Melillo P, Marshall K, et al.
Ophthalmology
. 2013 Mar;
120(6):1283-91.
PMID: 23474247
Objective: The aim of this study was to show the clinical data of long-term (3-year) follow-up of 5 patients affected by Leber congenital amaurosis type 2 (LCA2) treated with a...
36.
Ciesielska A, Hadaczek P, Mittermeyer G, Zhou S, Wright J, Bankiewicz K, et al.
Mol Ther
. 2012 Aug;
21(1):158-66.
PMID: 22929660
There is considerable interest in the use of adeno-associated virus serotype 9 (AAV9) for neurological gene therapy partly because of its ability to cross the blood-brain barrier to transduce astrocytes...
37.
Suhy D, Kao S, Mao T, Whiteley L, Denise H, Souberbielle B, et al.
Mol Ther
. 2012 Jun;
20(9):1737-1749.
PMID: 22735378
The hepatitis C virus (HCV) chronically infects 2% of the world population and effective treatment is limited by long duration and significant side-effects. Here, we describe a novel drug, intended...
38.
Mingozzi F, Chen Y, Murphy S, Edmonson S, Tai A, Price S, et al.
Mol Ther
. 2012 May;
20(7):1410-6.
PMID: 22565846
Liver gene transfer for hemophilia B has shown very promising results in recent clinical studies. A potential complication of gene-based treatments for hemophilia and other inherited disorders, however, is the...
39.
Fagone P, Wright J, Nathwani A, Nienhuis A, Davidoff A, Gray J
Hum Gene Ther Methods
. 2012 Mar;
23(1):1-7.
PMID: 22428975
Self-complementary AAV (scAAV) vector genomes contain a covalently closed hairpin derived from a mutated inverted terminal repeat that connects the two monomer single-stranded genomes into a head-to-head or tail-to-tail dimer....
40.
Bennett J, Ashtari M, Wellman J, Marshall K, Cyckowski L, Chung D, et al.
Sci Transl Med
. 2012 Feb;
4(120):120ra15.
PMID: 22323828
Demonstration of safe and stable reversal of blindness after a single unilateral subretinal injection of a recombinant adeno-associated virus (AAV) carrying the RPE65 gene (AAV2-hRPE65v2) prompted us to determine whether...