J Fraser Wright
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Explore the profile of J Fraser Wright including associated specialties, affiliations and a list of published articles.
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Recent Articles
21.
Wright J
Biomedicines
. 2017 May;
2(1):80-97.
PMID: 28548061
Adeno-associated virus (AAV)-based vectors expressing therapeutic genes continue to demonstrate great promise for the treatment of a wide variety of diseases and together with other gene transfer vectors represent an...
22.
Bennett J, Wellman J, Marshall K, McCague S, Ashtari M, DiStefano-Pappas J, et al.
Lancet
. 2016 Jul;
388(10045):661-72.
PMID: 27375040
Background: Safety and efficacy have been shown in a phase 1 dose-escalation study involving a unilateral subretinal injection of a recombinant adeno-associated virus (AAV) vector containing the RPE65 gene (AAV2-hRPE65v2)...
23.
Merten O, Wright J
Mol Ther Methods Clin Dev
. 2016 Apr;
3:16021.
PMID: 27110582
No abstract available.
24.
Lytle A, Brown H, Paik N, Knight K, Wright J, Spencer H, et al.
Mol Ther Methods Clin Dev
. 2016 Feb;
3:15056.
PMID: 26909355
Immune responses to coagulation factors VIII (FVIII) and IX (FIX) represent primary obstacles to hemophilia treatment. Previously, we showed that hematopoietic stem cell (HSC) retroviral gene therapy induces immune nonresponsiveness...
25.
van der Loo J, Wright J
Hum Mol Genet
. 2015 Nov;
25(R1):R42-52.
PMID: 26519140
Promising results in several clinical studies have emphasized the potential of gene therapy to address important medical needs and initiated a surge of investments in drug development and commercialization. This...
26.
Aalbers C, Bevaart L, Loiler S, de Cortie K, Wright J, Mingozzi F, et al.
PLoS One
. 2015 Jun;
10(6):e0130612.
PMID: 26107769
Introduction: Proof of concept for local gene therapy for the treatment of arthritis with immunomodulatory cytokine interferon beta (IFN-β) has shown promising results in animal models of rheumatoid arthritis (RA)....
27.
Bevaart L, Aalbers C, Vierboom M, Broekstra N, Kondova I, Breedveld E, et al.
Hum Gene Ther Clin Dev
. 2015 Jun;
26(2):103-12.
PMID: 26086763
Preclinical studies to assess biodistribution, safety, and initial efficacy of ART-I02, an adeno-associated type 5 (rAAV5) vector expressing human interferon β (hIFN-β), were performed in a total of 24 rhesus...
28.
Brown H, Wright J, Zhou S, Lytle A, Shields J, Spencer H, et al.
Mol Ther Methods Clin Dev
. 2015 May;
1:14036.
PMID: 26015976
Clinical data support the feasibility and safety of adeno-associated viral (AAV) vectors in gene therapy applications. Despite several clinical trials of AAV-based gene transfer for hemophilia B, a unique set...
29.
SAFETY AND TOLERABILITY OF MRI-GUIDED INFUSION OF AAV2-hAADC INTO THE MID-BRAIN OF NON-HUMAN PRIMATE
San Sebastian W, Kells A, Bringas J, Samaranch L, Hadaczek P, Ciesielska A, et al.
Mol Ther Methods Clin Dev
. 2014 Dec;
3.
PMID: 25541617
Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare, autosomal-recessive neurological disorder caused by mutations in the gene that leads to an inability to synthesize catecholamines and serotonin. As a...
30.
Ayuso E, Blouin V, Lock M, McGorray S, Leon X, Alvira M, et al.
Hum Gene Ther
. 2014 Oct;
25(11):977-87.
PMID: 25275822
Abstract Gene therapy approaches using recombinant adeno-associated virus serotype 2 (rAAV2) and serotype 8 (rAAV8) have achieved significant clinical benefits. The generation of rAAV Reference Standard Materials (RSM) is key...