J D McGarry
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Explore the profile of J D McGarry including associated specialties, affiliations and a list of published articles.
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130
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5078
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Recent Articles
1.
Brown N, Mullur R, Subramanian I, ESSER V, Bennett M, Saudubray J, et al.
J Lipid Res
. 2001 Jul;
42(7):1134-42.
PMID: 11441142
Carnitine palmitoyltransferase I (CPT I) catalyzes the formation of acylcarnitine, the first step in the oxidation of long-chain fatty acids in mitochondria. The enzyme exists as liver (L-CPT I) and...
2.
McGarry J
Biochem Soc Trans
. 2001 May;
29(Pt 2):241-5.
PMID: 11356162
Although malonyl-CoA was first recognized as a central component in the regulation of hepatic ketogenesis, its inhibitory effect on mitochondrial carnitine palmitoyltransferase I (CPT I) has come to be viewed...
3.
Caserta F, Tchkonia T, Civelek V, Prentki M, Brown N, McGarry J, et al.
Am J Physiol Endocrinol Metab
. 2001 Feb;
280(2):E238-47.
PMID: 11158926
Regional differences in free fatty acid (FFA) handling contribute to diseases associated with particular fat distributions. As cultured rat preadipocytes became differentiated, FFA transfer into preadipocytes increased and was more...
4.
Dobbins R, Szczepaniak L, Bentley B, ESSER V, Myhill J, McGarry J
Diabetes
. 2001 Jan;
50(1):123-30.
PMID: 11147777
Cross-sectional studies in human subjects have used 1H magnetic resonance spectroscopy (HMRS) to demonstrate that insulin resistance correlates more tightly with the intramyocellular lipid (IMCL) concentration than with any other...
5.
Mulder H, Lu D, Finley 4th J, An J, Cohen J, Antinozzi P, et al.
J Biol Chem
. 2000 Dec;
276(9):6479-84.
PMID: 11113153
The long-chain acyl-CoA (LC-CoA) model of glucose-stimulated insulin secretion (GSIS) holds that secretion is linked to a glucose-induced increase in malonyl-CoA level and accumulation of LC-CoA in the cytosol. We...
6.
7.
Baillet L, Mullur R, ESSER V, McGarry J
J Biol Chem
. 2000 Sep;
275(47):36766-8.
PMID: 10986294
It is well established that medium and long chain (+)-acylcarnitines (i.e. fatty acid esters of the unnatural d-isomer of carnitine) inhibit the oxidation of long chain fatty acids in mammalian...
8.
Mutomba M, Yuan H, Konyavko M, Adachi S, Yokoyama C, ESSER V, et al.
FEBS Lett
. 2000 Aug;
478(1-2):19-25.
PMID: 10922462
L-Carnitine facilitates the transport of fatty acids into the mitochondrial matrix where they are used for energy production. Recent studies have shown that L-carnitine is capable of protecting the heart...
9.
McGarry J, Brown N
Biochem J
. 2000 Jun;
349(Pt 1):179-87.
PMID: 10861226
Carnitine palmitoyltransferase I (CPT I) catalyses the initial step of fatty acid import into the mitochondrial matrix, the site of beta-oxidation, and its inhibition by malonyl-CoA is a primary control...
10.
Szczepaniak L, Babcock E, Schick F, Dobbins R, Garg A, Burns D, et al.
Am J Physiol
. 1999 May;
276(5):E977-89.
PMID: 10329993
We validate the use of 1H magnetic resonance spectroscopy (MRS) to quantitatively differentiate between adipocyte and intracellular triglyceride (TG) stores by monitoring the TG methylene proton signals at 1.6 and...