Izumi Iida
Overview
Explore the profile of Izumi Iida including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
109
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0
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Recent Articles
1.
Kakegawa W, Paternain A, Matsuda K, Aller M, Iida I, Miura E, et al.
Cell Rep
. 2024 Jul;
43(7):114427.
PMID: 38986610
Kainate (KA)-type glutamate receptors (KARs) are implicated in various neuropsychiatric and neurological disorders through their ionotropic and metabotropic actions. However, compared to AMPA- and NMDA-type receptor functions, many aspects of...
2.
Iida I, Konno K, Natsume R, Abe M, Watanabe M, Sakimura K, et al.
Sci Rep
. 2024 Feb;
14(1):4521.
PMID: 38402313
Kainate receptors (KARs) are one of the ionotropic glutamate receptors in the central nervous system (CNS) comprised of five subunits, GluK1-GluK5. There is a growing interest in the association between...
3.
Komatsu A, Iida I, Nasu Y, Ito G, Harada F, Kishikawa S, et al.
J Biol Chem
. 2022 Apr;
298(5):101933.
PMID: 35427648
Hyperammonemia is known to cause various neurological dysfunctions such as seizures and cognitive impairment. Several studies have suggested that hyperammonemia may also be linked to the development of Alzheimer's disease...
4.
Yamada Y, Nihara J, Trakanant S, Kudo T, Seo K, Iida I, et al.
Neurosci Res
. 2021 Jun;
173:62-70.
PMID: 34174368
Hh signaling has been shown to be activated in intact and injured peripheral nerve. However, the role of Hh signaling in peripheral nerve is not fully understood. In the present...
5.
Iida I, Konno K, Natsume R, Abe M, Watanabe M, Sakimura K, et al.
Behav Brain Res
. 2021 Feb;
405:113194.
PMID: 33631192
Kainate receptors (KARs) are members of the glutamate receptor family that regulate synaptic function in the brain. Although they are known to be associated with psychiatric disorders, how they are...
6.
Hikichi H, Hiyoshi T, Marumo T, Tomishima Y, Kaku A, Iida I, et al.
J Pharmacol Sci
. 2015 Apr;
127(3):352-61.
PMID: 25837934
Glutamatergic dysfunction has been implicated in psychiatric disorders such as schizophrenia. The stimulation of metabotropic glutamate (mGlu) 2 receptor has been shown to be effective in a number of animal...
7.
Hiyoshi T, Marumo T, Hikichi H, Tomishima Y, Urabe H, Tamita T, et al.
J Pharmacol Exp Ther
. 2014 Oct;
351(3):642-53.
PMID: 25277141
Excess glutamatergic neurotransmission has been implicated in the pathophysiology of schizophrenia, and the activation of metabotropic glutamate 2 (mGlu2) receptor may exert antipsychotic effects by normalizing glutamate transmission. In the...
8.
Kakinuma H, Oi T, Hashimoto-Tsuchiya Y, Arai M, Kawakita Y, Fukasawa Y, et al.
J Med Chem
. 2010 Mar;
53(8):3247-61.
PMID: 20302302
Derivatives of a novel scaffold, C-phenyl 1-thio-D-glucitol, were prepared and evaluated for sodium-dependent glucose cotransporter (SGLT) 2 and SGLT1 inhibition activities. Optimization of substituents on the aromatic rings afforded five...
9.
Ohta H, Ishizaka T, Tatsuzuki M, Yoshinaga M, Iida I, Yamaguchi T, et al.
Bioorg Med Chem
. 2007 Nov;
16(3):1111-24.
PMID: 18006322
In this study, a novel series of CB(2) receptor agonist imine derivatives, 1-6, was synthesized and evaluated for activity against the CB(2) receptor. In a previous paper we reported the...
10.
Ohta H, Ishizaka T, Tatsuzuki M, Yoshinaga M, Iida I, Tomishima Y, et al.
Bioorg Med Chem Lett
. 2007 Sep;
17(22):6299-304.
PMID: 17884496
A novel series of N-alkylidenearylcarboxamides 4, a CB(2) receptor agonist, were synthesized and evaluated for activity against the human CB(2) receptor. In a previous paper, we reported that sulfonamide derivative...