Ivan Psakhye
Overview
Explore the profile of Ivan Psakhye including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
905
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0
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Recent Articles
1.
Psakhye I, Kawasumi R, Abe T, Hirota K, Branzei D
Nat Struct Mol Biol
. 2023 Aug;
30(9):1286-1294.
PMID: 37592094
Sister chromatid cohesion, established during replication by the ring-shaped multiprotein complex cohesin, is essential for faithful chromosome segregation. Replisome-associated proteins are required to generate cohesion by two independent pathways. One...
2.
Kawasumi R, Abe T, Psakhye I, Miyata K, Hirota K, Branzei D
Genes Dev
. 2021 Sep;
35(19-20):1368-1382.
PMID: 34503989
The alternative PCNA loader containing CTF18-DCC1-CTF8 facilitates sister chromatid cohesion (SCC) by poorly defined mechanisms. Here we found that in DT40 cells, CTF18 acts complementarily with the Warsaw breakage syndrome...
3.
Psakhye I, Branzei D
Cell Rep
. 2021 Aug;
36(5):109485.
PMID: 34348159
Structural maintenance of chromosomes (SMCs) complexes, cohesin, condensin, and Smc5/6, are essential for viability and participate in multiple processes, including sister chromatid cohesion, chromosome condensation, and DNA repair. Here we...
4.
Psakhye I, Castellucci F, Branzei D
Mol Cell
. 2019 Sep;
76(4):632-645.e6.
PMID: 31519521
Similar to ubiquitin, SUMO forms chains, but the identity of SUMO-chain-modified factors and the purpose of this modification remain largely unknown. Here, we identify the budding yeast SUMO protease Ulp2,...
5.
Paasch F, den Brave F, Psakhye I, Pfander B, Jentsch S
J Biol Chem
. 2017 Nov;
293(2):599-609.
PMID: 29183993
Modification by the ubiquitin-like protein SUMO affects hundreds of cellular substrate proteins and regulates a wide variety of physiological processes. While the SUMO system appears to predominantly target nuclear proteins...
6.
Psakhye I, Jentsch S
Methods Mol Biol
. 2016 Sep;
1475:219-31.
PMID: 27631809
Protein modification by conjugation to the ubiquitin-related protein SUMO (SUMOylation) regulates numerous cellular functions and is reversible. However, unlike typical posttranslational modifications, SUMOylation often targets and regulates proteins of functionally...
7.
Branzei D, Psakhye I
Curr Opin Cell Biol
. 2016 Apr;
40:137-144.
PMID: 27060551
Accurate chromosomal DNA replication is fundamental for optimal cellular function and genome integrity. Replication perturbations activate DNA damage tolerance pathways, which are crucial to complete genome duplication as well as...
8.
Lu K, Psakhye I, Jentsch S
Autophagy
. 2014 Dec;
10(12):2381-2.
PMID: 25470352
Selective ubiquitin-dependent autophagy mediates the disposal of superfluous cellular structures and clears cells of protein aggregates such as polyQ proteins linked to Huntington disease. Crucial selectivity factors of this pathway...
9.
Lu K, Psakhye I, Jentsch S
Cell
. 2014 Jul;
158(3):549-63.
PMID: 25042851
Selective ubiquitin-dependent autophagy plays a pivotal role in the elimination of protein aggregates, assemblies, or organelles and counteracts the cytotoxicity of proteins linked to neurodegenerative diseases. Following substrate ubiquitylation, the...
10.
Gonzalez-Huici V, Szakal B, Urulangodi M, Psakhye I, Castellucci F, Menolfi D, et al.
EMBO J
. 2014 Jan;
33(4):327-40.
PMID: 24473148
DNA replication is sensitive to damage in the template. To bypass lesions and complete replication, cells activate recombination-mediated (error-free) and translesion synthesis-mediated (error-prone) DNA damage tolerance pathways. Crucial for error-free...