Dana Branzei
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Explore the profile of Dana Branzei including associated specialties, affiliations and a list of published articles.
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94
Citations
4100
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Recent Articles
1.
Branzei D, Bene S, Gangwani L, Szakal B
DNA Repair (Amst)
. 2024 Aug;
142:103742.
PMID: 39137555
At the core of cellular life lies a carefully orchestrated interplay of DNA replication, recombination, chromatin assembly, sister-chromatid cohesion and transcription. These fundamental processes, while seemingly discrete, are inextricably linked...
2.
Kannan A, Gangadharan Leela S, Branzei D, Gangwani L
Brain Commun
. 2024 Jul;
6(4):fcae239.
PMID: 39070547
Senataxin is an RNA:DNA helicase that plays an important role in the resolution of RNA:DNA hybrids (R-loops) formed during transcription. R-loops are involved in the regulation of biological processes such...
3.
Szakal B, Giannattasio M, Branzei D
Mol Cell
. 2024 Jan;
84(1):182-182.e1.
PMID: 38181760
Completion of DNA replication relies on the ability of replication forks to traverse various types of DNA damage, actively transcribed regions, and structured DNA. The mechanisms enabling these processes are...
4.
Nunomiya A, Szakal B, Branzei D
Mol Cell
. 2024 Jan;
84(1):180-180.e1.
PMID: 38181759
The genetic information stored in DNA is under continuous threat by endogenous and environmental sources of DNA damage. Cells have evolved multiple DNA repair pathways that function in overlapping manners,...
5.
Boavida A, Napolitano L, Santos D, Cortone G, Jegadesan N, Onesti S, et al.
EMBO Rep
. 2024 Jan;
25(2):876-901.
PMID: 38177925
FANCJ, a DNA helicase linked to Fanconi anemia and frequently mutated in cancers, counteracts replication stress by dismantling unconventional DNA secondary structures (such as G-quadruplexes) that occur at the DNA...
6.
Szakal B, Branzei D
Mol Oncol
. 2023 Sep;
17(10):1950-1952.
PMID: 37681281
A new study by Longo, Roy et al. has solved the structure of the RAD51C-XRCC3 (CX3) heterodimer with a bound ATP analog, identifying two main structural interfaces and defining separable...
7.
Psakhye I, Kawasumi R, Abe T, Hirota K, Branzei D
Nat Struct Mol Biol
. 2023 Aug;
30(9):1286-1294.
PMID: 37592094
Sister chromatid cohesion, established during replication by the ring-shaped multiprotein complex cohesin, is essential for faithful chromosome segregation. Replisome-associated proteins are required to generate cohesion by two independent pathways. One...
8.
Joseph C, Dusi S, Giannattasio M, Branzei D
Nat Commun
. 2022 May;
13(1):2480.
PMID: 35513396
DNA damage tolerance (DDT), activated by replication stress during genome replication, is mediated by translesion synthesis and homologous recombination (HR). Here we uncover that DDK kinase, essential for replication initiation,...
9.
Dolce V, Dusi S, Giannattasio M, Joseph C, Fumasoni M, Branzei D
Genes Dev
. 2022 Feb;
36(3-4):167-179.
PMID: 35115379
Ctf4 is a conserved replisome component with multiple roles in DNA metabolism. To investigate connections between Ctf4-mediated processes involved in drug resistance, we conducted a suppressor screen of Δ sensitivity...
10.
Kannan A, Cuartas J, Gangwani P, Branzei D, Gangwani L
Brain
. 2022 Jan;
145(9):3072-3094.
PMID: 35045161
Mutation in the senataxin (SETX) gene causes an autosomal dominant neuromuscular disorder, amyotrophic lateral sclerosis 4 (ALS4), characterized by degeneration of motor neurons, muscle weakness and atrophy. SETX is an...