Itziar Muneta-Arrate
Overview
Explore the profile of Itziar Muneta-Arrate including associated specialties, affiliations and a list of published articles.
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11
Citations
31
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Recent Articles
1.
Bagan A, Abas S, Pala-Pujadas J, Irisarri A, Grinan-Ferre C, Pallas M, et al.
Bioorg Chem
. 2024 Nov;
142:106935.
PMID: 39492364
Recent studies pointed out the modulation of imidazoline I receptors (I-IR) by selective ligands as a putative strategy to face neurodegenerative diseases. Foregoing the classical 2-imidazoline/imidazole-containing I-IR ligands, we report...
2.
Wright S, Avet C, Gaitonde S, Muneta-Arrate I, Le Gouill C, Hogue M, et al.
Sci Signal
. 2024 Jun;
17(841):eadi4747.
PMID: 38889226
G protein-coupled receptors (GPCRs) regulate cellular signaling processes by coupling to diverse combinations of heterotrimeric G proteins composed of Gα, Gβ, and Gγ subunits. Biosensors based on bioluminescence resonance energy...
3.
Kossatz E, Diez-Alarcia R, Gaitonde S, Ramon-Duaso C, Stepniewski T, Aranda-Garcia D, et al.
Nat Commun
. 2024 May;
15(1):4307.
PMID: 38811567
G protein-coupled receptors (GPCRs) are sophisticated signaling machines able to simultaneously elicit multiple intracellular signaling pathways upon activation. Complete (in)activation of all pathways can be counterproductive for specific therapeutic applications....
4.
Muneta-Arrate I, Miranda-Azpiazu P, Horrillo I, Diez-Alarcia R, Meana J
Br J Pharmacol
. 2024 Apr;
PMID: 38644550
Background And Purpose: Whereas biased agonism on the 5-HT receptor has been ascribed to hallucinogenic properties of psychedelics, no information about biased inverse agonism on this receptor is available. In...
5.
Villa M, Martinez-Vega M, Silva L, Muneta-Arrate I, Gomez-Soria A, Muguruza C, et al.
Pediatr Res
. 2024 Feb;
95(7):1783-1790.
PMID: 38360979
Background: Neonatal rats can manifest post-stroke mood disorders (PSMD) following middle cerebral artery occlusion (MCAO). We investigated whether cannabidiol (CBD) neuroprotection, previously demonstrated in neonatal rats after MCAO, includes prevention...
6.
Albujuq N, Meana J, Diez-Alarcia R, Muneta-Arrate I, Naqvi A, Althumayri K, et al.
J Med Chem
. 2023 Jun;
66(13):9057-9075.
PMID: 37378639
There is concern for important adverse effects with use of second-generation antipsychotics in Parkinson's disease psychosis (PDP) and dementia-related psychosis. Pimavanserin is the only antipsychotic drug authorized for PDP and...
7.
Villa M, Martinez-Vega M, Del Pozo A, Muneta-Arrate I, Gomez-Soria A, Muguruza C, et al.
Int J Mol Sci
. 2023 Feb;
24(4).
PMID: 36834637
Post-stroke mood disorders (PSMD) affect disease prognosis in adults. Adult rodent models underlie the importance of the dopamine (DA) system in PSMD pathophysiology. There are no studies on PSMD after...
8.
Diez-Alarcia R, Odagaki Y, Miranda-Azpiazu P, Gabilondo A, Meana J, Muneta-Arrate I
Pharmacol Rep
. 2021 May;
73(4):1203.
PMID: 33956329
No abstract available.
9.
Diez-Alarcia R, Odagaki Y, Miranda-Azpiazu P, Gabilondo A, Meana J, Muneta-Arrate I
Pharmacol Rep
. 2021 Apr;
73(4):1079-1095.
PMID: 33876404
G-protein-coupled receptors (GPCRs) have an enormous biochemical importance as they bind to diverse extracellular ligands and regulate a variety of physiological and pathological responses. G-protein activation measures the functional consequence...
10.
Muneta-Arrate I, Diez-Alarcia R, Horrillo I, Meana J
Eur Neuropsychopharmacol
. 2020 Jun;
36:83-89.
PMID: 32517960
Pimavanserin is claimed as the first antipsychotic drug that shows selectivity for serotonin 5-HT receptors (5-HTRs) and lacks of affinity for dopamine D receptors (DRs). Cell-based functional assays suggest that...