Rebeca Diez-Alarcia
Overview
Explore the profile of Rebeca Diez-Alarcia including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
318
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Recent Articles
1.
Bagan A, Lopez-Ruiz A, Abas S, Ruiz-Cantero M, Vasilopoulou F, Taboada-Jara T, et al.
J Med Chem
. 2025 Jan;
68(3):2551-2573.
PMID: 39818939
Imidazoline receptors (I-IRs) are altered in Alzheimer's disease (AD) patients and are associated with analgesia. I-IRs are not structurally described, and their pharmacological characterization relies on their modulation by highly...
2.
Wright S, Avet C, Gaitonde S, Muneta-Arrate I, Le Gouill C, Hogue M, et al.
Sci Signal
. 2024 Jun;
17(841):eadi4747.
PMID: 38889226
G protein-coupled receptors (GPCRs) regulate cellular signaling processes by coupling to diverse combinations of heterotrimeric G proteins composed of Gα, Gβ, and Gγ subunits. Biosensors based on bioluminescence resonance energy...
3.
Kossatz E, Diez-Alarcia R, Gaitonde S, Ramon-Duaso C, Stepniewski T, Aranda-Garcia D, et al.
Nat Commun
. 2024 May;
15(1):4307.
PMID: 38811567
G protein-coupled receptors (GPCRs) are sophisticated signaling machines able to simultaneously elicit multiple intracellular signaling pathways upon activation. Complete (in)activation of all pathways can be counterproductive for specific therapeutic applications....
4.
Muneta-Arrate I, Miranda-Azpiazu P, Horrillo I, Diez-Alarcia R, Meana J
Br J Pharmacol
. 2024 Apr;
PMID: 38644550
Background And Purpose: Whereas biased agonism on the 5-HT receptor has been ascribed to hallucinogenic properties of psychedelics, no information about biased inverse agonism on this receptor is available. In...
5.
Costas-Insua C, Hermoso-Lopez A, Moreno E, Montero-Fernandez C, Alvaro-Blazquez A, Maroto I, et al.
EMBO Mol Med
. 2024 Mar;
16(4):755-783.
PMID: 38514794
Cereblon/CRBN is a substrate-recognition component of the Cullin4A-DDB1-Roc1 E3 ubiquitin ligase complex. Destabilizing mutations in the human CRBN gene cause a form of autosomal recessive non-syndromic intellectual disability (ARNSID) that...
6.
DelaCuesta-Barrutia J, Martinez-Peula O, Rivero G, Santas-Martin J, Munarriz-Cuezva E, Brocos-Mosquera I, et al.
Transl Psychiatry
. 2024 Feb;
14(1):113.
PMID: 38396013
Antipsychotic-induced low availability of group II metabotropic glutamate receptors (including mGluR and mGluR) in brains of schizophrenia patients may explain the limited efficacy of mGluR ligands in clinical trials. Studies...
7.
Maroto I, Moreno E, Costas-Insua C, Merino-Gracia J, Diez-Alarcia R, Alvaro-Blazquez A, et al.
Neuropharmacology
. 2023 Sep;
240:109712.
PMID: 37689260
Cannabinoids exert pleiotropic effects on the brain by engaging the cannabinoid CB receptor (CBR), a presynaptic metabotropic receptor that regulates key neuronal functions in a highly context-dependent manner. We have...
8.
Albujuq N, Meana J, Diez-Alarcia R, Muneta-Arrate I, Naqvi A, Althumayri K, et al.
J Med Chem
. 2023 Jun;
66(13):9057-9075.
PMID: 37378639
There is concern for important adverse effects with use of second-generation antipsychotics in Parkinson's disease psychosis (PDP) and dementia-related psychosis. Pimavanserin is the only antipsychotic drug authorized for PDP and...
9.
Unzueta-Larrinaga P, Barrena-Barbadillo R, Ibarra-Lecue I, Horrillo I, Villate A, Recio M, et al.
Mol Neurobiol
. 2023 Apr;
60(8):4472-4487.
PMID: 37118325
The study of psychiatric and neurological diseases requires the substrate in which the disorders occur, that is, the nervous tissue. Currently, several types of human bio-specimens are being used for...
10.
Costas-Insua C, Moreno E, Maroto I, Ruiz-Calvo A, Bajo-Graneras R, Martin-Gutierrez D, et al.
J Neurosci
. 2021 Aug;
41(38):7924-7941.
PMID: 34353897
Cannabinoids, the bioactive constituents of cannabis, exert a wide array of effects on the brain by engaging Type 1 cannabinoid receptor (CBR). Accruing evidence supports that cannabinoid action relies on...