Isabelle Green
Overview
Explore the profile of Isabelle Green including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
222
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0
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Recent Articles
1.
Marusiak A, Stephenson N, Baik H, Trotter E, Li Y, Blyth K, et al.
Cancer Res
. 2015 Dec;
76(3):724-35.
PMID: 26637668
MLK4 is a member of the mixed-lineage family of kinases that regulate the JNK, p38, and ERK kinase signaling pathways. MLK4 mutations have been identified in various human cancers, including...
2.
Dakin L, Block M, Chen H, Code E, Dowling J, Feng X, et al.
Bioorg Med Chem Lett
. 2012 Jun;
22(14):4599-604.
PMID: 22727640
Novel substituted benzylidene-1,3-thiazolidine-2,4-diones (TZDs) have been identified as potent and highly selective inhibitors of the PIM kinases. The synthesis and SAR of these compounds are described, along with X-ray crystallographic,...
3.
Brading R, Abbott W, Green I, Davies A, McCall E
Protein Expr Purif
. 2012 May;
83(2):217-25.
PMID: 22542589
The activity of kinases is regulated by phosphorylation on Ser, Thr or Tyr residues within the activation loop. The ability to produce these enzymes recombinantly with a specific phosphorylation status...
4.
Ferguson A, Larsen N, Howard T, Pollard H, Green I, Grande C, et al.
Structure
. 2011 Jul;
19(9):1262-73.
PMID: 21782458
Protein lysine methyltransferases are important regulators of epigenetic signaling. These enzymes catalyze the transfer of donor methyl groups from S-adenosylmethionine to specific acceptor lysines on histones, leading to changes in...
5.
Ioannidis S, Lamb M, Wang T, Almeida L, Block M, Davies A, et al.
J Med Chem
. 2010 Dec;
54(1):262-76.
PMID: 21138246
The myeloproliferative neoplasms, polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis are a heterogeneous but related group of hematological malignancies characterized by clonal expansion of one or more myeloid lineages. The...
6.
Bardelle C, Barlaam B, Brooks N, Coleman T, Cross D, Ducray R, et al.
Bioorg Med Chem Lett
. 2010 Sep;
20(21):6242-5.
PMID: 20850301
Starting from the initial bis-anilinopyrimidine 1, good potency against EphB4 was retained when benzodioxole at C-4 was replaced by an indazole. The key interactions of the indazole with the protein...
7.
Green I, Christison R, Voyce C, Bundell K, Lindsay M
Trends Pharmacol Sci
. 2003 May;
24(5):213-5.
PMID: 12767716
Early studies with protein transduction domains (PTDs), such as those derived from Tat and Drosophila Antennapedia, showed rapid, receptor- and endosomal-independent uptake of conjugated biological tools into all cell types....