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Discovery of Novel Benzylidene-1,3-thiazolidine-2,4-diones As Potent and Selective Inhibitors of the PIM-1, PIM-2, and PIM-3 Protein Kinases

Abstract

Novel substituted benzylidene-1,3-thiazolidine-2,4-diones (TZDs) have been identified as potent and highly selective inhibitors of the PIM kinases. The synthesis and SAR of these compounds are described, along with X-ray crystallographic, anti-proliferative, and selectivity data.

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